(Q24650602)

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Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

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Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs) (English)

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P. Jeffrey Conn

7

object named as

P Jeffrey Conn

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Colleen M. Niswender

2

object named as

Colleen M Niswender

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Craig W. Lindsley

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object named as

Craig W Lindsley

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5

object named as

Usha N Menon

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Corey R. Hopkins

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object named as

Corey R Hopkins

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Darren W. Engers

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object named as

Darren W Engers

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6

object named as

Rocio Zamorano

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author name string

C David Weaver

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Satyawan Jadhav

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language of work or name

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publication date

23 July 2009

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Journal of Medicinal Chemistry

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52

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14

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4115-8

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1 reference

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1 reference

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7 April 2017

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1 reference

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Ligand efficiency: a useful metric for lead selection

1 reference

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7 April 2017

Pharmacology and functions of metabotropic glutamate receptors

1 reference

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7 April 2017

mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

1 reference

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28 September 2017

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

1 reference

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28 September 2017

Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators

1 reference

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28 September 2017

Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

1 reference

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28 September 2017

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo

1 reference

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(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

1 reference

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Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries

1 reference

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28 September 2017

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1 reference

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28 September 2017

Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse.

1 reference

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30 May 2018

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1 reference

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28 November 2018

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10.1021/JM9005065

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