(Q24652121)

English

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease

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scholarly article

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Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease (English)

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author name string

B Gooptu

1

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B Hazes

2

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W S Chang

3

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T R Dafforn

4

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R W Carrell

5

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R J Read

6

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D A Lomas

7

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language of work or name

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publication date

4 January 2000

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Proceedings of the National Academy of Sciences of the United States of America

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97

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1

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67-72

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Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

Biological implications of a 3 A structure of dimeric antithrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7 A resolution and its comparison with other serpins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

The CCP4 suite: programs for protein crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

https://api.crossref.org/works/10.1073/PNAS.97.1.67

22 April 2017

Improved R-factors for diffraction data analysis in macromolecular crystallography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

Familial dementia caused by polymerization of mutant neuroserpin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

Inhibition of human neutrophil superoxide generation by alpha 1-antichymotrypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

7 April 2017

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 September 2017

Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 September 2017

The molecular basis of alpha 1-antichymotrypsin deficiency in a heterozygote with liver and lung disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 September 2017

Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 September 2017

Stimulatory effect of inflammatory cytokines on alpha 1-antichymotrypsin expression in human lung-derived epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 September 2017

What do dysfunctional serpins tell us about molecular mobility and disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 September 2017

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 September 2017

Genetics and respiratory disease. 2. Alpha 1-antitrypsin deficiency, cirrhosis and emphysema

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

30 May 2018

A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

30 May 2018

Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

30 May 2018

Sequential changes of plasma proteins after surgical trauma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

30 May 2018

Structural basis of latency in plasminogen activator inhibitor-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

19 June 2018

Latent alpha1-antichymotrypsin. A molecular explanation for the inactivation of alpha1-antichymotrypsin in chronic bronchitis and emphysema.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

AMoRe: an automated package for molecular replacement

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

[Model phases: probabilities and bias.

1 reference

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28 November 2018

Commercial antithrombin concentrate contains inactive L-forms of antithrombin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=26617

28 November 2018

The control of neutrophil chemotaxis by inhibitors of cathepsin G and chymotrypsin

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Role of the P6-P3' region of the serpin reactive loop in the formation and breakdown of the inhibitory complex

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Stopped flow fluorescence energy transfer measurement of the rate constants describing the reversible formation and the irreversible rearrangement of the elastase-alpha1-proteinase inhibitor complex

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Antichymotrypsin interaction with chymotrypsin. Intermediates on the way to inhibited complex formation

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

Modeling of serpin-protease complexes: antithrombin-thrombin, alpha 1-antitrypsin (358Met-->Arg)-thrombin, alpha 1-antitrypsin (358Met-->Arg)-trypsin, and antitrypsin-elastase

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.1.67

21 January 2018

alpha 1-Antichymotrypsin in lung secretions is not an effective proteinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10618372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 1-antitrypsin Siiyama (Ser53-->Phe). Further evidence for intracellular loop-sheet polymerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/10618372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of antithrombin polymerisation and heparin activation probed by the insertion of synthetic reactive loop peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/10618372

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.97.1.67

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2000PNAS...97...67G

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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