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Unravelling the brain targets of gamma-hydroxybutyric acid
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review article
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title
Unravelling the brain targets of gamma-hydroxybutyric acid
(English)
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main subject
drug discovery
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author
Nathalie Leresche
series ordinal
3
object named as
Nathalie Leresche
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author name string
Vincenzo Crunelli
series ordinal
1
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Zsuzsa Emri
series ordinal
2
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language of work or name
English
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publication date
February 2006
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published in
Current Opinion in Pharmacology
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volume
6
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issue
1
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page(s)
44-52
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cites work
Gamma-hydroxybutyrate reduces mitogen-activated protein kinase phosphorylation via GABA B receptor activation in mouse frontal cortex and hippocampus
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Gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence.
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Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures.
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Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid.
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Generalities concerning the experimental study and clinical use of gamma hydroxybutyrate of Na.
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Gamma-hydroxybutyrate receptor function determined by stimulation of rubidium and calcium movements from NCB-20 neurons
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Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men.
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Treatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findings.
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Sleep patterns in cat induced by gammahydroxybutyric acid
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Gamma-hydroxybutyric acid decreases thalamic sensory excitatory postsynaptic potentials by an action on presynaptic GABAB receptors.
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gamma-Hydroxybutyric acid increases intracellular Ca2+ concentration and nuclear cyclic AMP-responsive element- and activator protein 1 DNA-binding activities through GABAB receptor in cultured cerebellar granule cells.
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Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam
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Novel gamma-hydroxybutyric acid (GHB) analogs share some, but not all, of the behavioral effects of GHB and GABAB receptor agonists
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28 November 2018
Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons
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28 November 2018
Gamma-hydroxybutyric acid (GHB) and the mesoaccumbens reward circuit: evidence for GABA(B) receptor-mediated effects
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28 November 2018
Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons
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28 November 2018
Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy.
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28 November 2018
Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system
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28 November 2018
The Discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: The role of GABA(B) and GABA(A) receptors
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28 November 2018
Gamma-hydroxybutyrate and ethanol depress spontaneous excitatory postsynaptic currents in dopaminergic neurons of the substantia nigra
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28 November 2018
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice
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28 November 2018
GAMMA-HYDROXYBUTYRATE, A NORMAL BRAIN METABOLITE.
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28 November 2018
Quantitative autoradiographic analysis of the new radioligand [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382) at gamma-hydroxybutyric acid (GHB) binding sites in rat brain
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28 November 2018
The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies
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PubMed Central
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28 November 2018
Stereoselectivity of NCS-382 binding to gamma-hydroxybutyrate receptor in the rat brain.
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PubMed Central
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28 November 2018
GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid
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28 November 2018
Evidence for a gamma-hydroxybutyrate (GHB) uptake by rat brain synaptic vesicles.
1 reference
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28 November 2018
Binding characteristics of the gamma-hydroxybutyric acid receptor antagonist [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid in the rat brain
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174623
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28 November 2018
Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174623
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28 November 2018
gamma-Hydroxybutyrate modulation of glutamate levels in the hippocampus: an in vivo and in vitro study
1 reference
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PubMed Central
reference URL
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28 November 2018
GHB depresses fast excitatory and inhibitory synaptic transmission via GABA(B) receptors in mouse neocortical neurons.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174623
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28 November 2018
Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.
1 reference
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PubMed Central
reference URL
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28 November 2018
gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.
1 reference
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PubMed Central
reference URL
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28 November 2018
The ontogeny of [3H]gamma-hydroxybutyrate and [3H]GABAB binding sites: relation to the development of experimental absence seizures
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PubMed Central
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28 November 2018
Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB, receptor-mediated hyperpolarization.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2174623
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28 November 2018
Quantitative autoradiographic distribution of γ-hydroxybutyric acid binding sites in human and monkey brain
1 reference
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PubMed
reference URL
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12 December 2020
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A 12-month, open-label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsy
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16368267
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12 December 2020
based on heuristic
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The effects of the combined administration of gamma-hydroxybutyrate and diazepam on sleep parameters in the rat
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16368267
retrieved
12 December 2020
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DOI
10.1016/J.COPH.2005.10.001
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release_6eh7zmelljf5xjyk4mbcvw7mcm
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PMC publication ID
2174623
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PubMed publication ID
16368267
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7403127
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