(Q24672483)

English

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

0 references

1 reference

Europe PubMed Central

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors (English)

0 references

David Colquhoun

1

object named as

D Colquhoun

0 references

author name string

D Colquhoun

1

0 references

language of work or name

0 references

publication date

November 1998

0 references

British Journal of Pharmacology

0 references

125

0 references

5

0 references

924-47

0 references

Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Some quantitative uses of drug antagonists

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

How receptors talk to trimeric G proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Allosteric proteins: from regulatory enzymes to receptors--personal recollections

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the gamma-subunit of the Torpedo nicotinic acetylcholine receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

The G-protein nanomachine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

The elusive nature of intrinsic efficacy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular pharmacology. The binding issue.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Action of brief pulses of glutamate on AMPA/kainate receptors in patches from different neurones of rat hippocampal slices

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of ion channels in the frog end-plate by high concentrations of acetylcholine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

From muscle endplate to brain synapses: a short history of synapses and agonist-activated ion channels

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction at End-Plate Receptors between Different Choline Derivatives

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Cooperative Interactions of Hemoglobin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of activation of muscle nicotinic acetylcholine receptors and the time course of endplate currents.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

A molecular scheme for the reaction between acetylcholine and nicotinic channels

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Conductances of single ion channels opened by nicotinic agonists are indistinguishable

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

The mode of action of nicotine and curari, determined by the form of the contraction curve and the method of temperature coefficients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure‐activity relationships for transmembrane signaling: the receptor's turn

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Muscarinic receptor subtypes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Single channel currents in the nicotinic acetylcholine receptor: a direct demonstration of allosteric transitions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Finding affinity constants for agonists by the irreversible antagonists method

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Agonist-specific receptor conformations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Further concerns over Cheng-Prusoff analysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Promiscuity, pre-coupling and instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Constraining ligand-binding site stoichiometry suggests that a cyclic nucleotide-gated channel is composed of two functional dimers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

The channel opening rate of adult- and fetal-type mouse muscle nicotinic receptors activated by acetylcholine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Cuddling up to channel activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Teleonomic mechanisms in cellular metabolism, growth, and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Allosteric proteins and cellular control systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Validation of Furchgott's method to determine agonist-dependent A1-adenosine receptor reserve in guinea-pig atrium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Time course of the increase in the myocardial slow inward current after a photochemically generated concentration jump of intracellular cAMP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

On the time course of the acetylcholine-induced hyperpolarization in quiescent guinea-pig atria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Maximum likelihood estimation of aggregated Markov processes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular mechanisms of inherited startle syndromes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

The tetrameric structure of a glutamate receptor channel

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Single cyclic nucleotide-gated channels locked in different ligand-bound states.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

pAx and competitive drug antagonism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Calculation of diffusion-limited kinetics for the reactions in collision coupling and receptor cross-linking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutational studies of protein structures and their stabilities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Acetylcholine receptor channel imaged in the open state

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy. I: A new method for estimating relative efficacy of full agonists via a newly defined efficacy related parameter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Genes at the junction--candidates for congenital myasthenic syndromes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation in the M1 domain of the acetylcholine receptor alpha subunit decreases the rate of agonist dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Rescue of functional interactions between the alpha2A-adrenoreceptor and acylation-resistant forms of Gi1alpha by expressing the proteins from chimeric open reading frames.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential transcriptional activation in vitro by NF-kappa B/Rel proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702164

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.BJP.0702164

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q24672483&oldid=1961428668"