(Q24791364)

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The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation

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scholarly article

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The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation (English)

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3

object named as

Jeffrey Wilusz

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author name string

Mythily Sachchithananthan

1

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Stan J Stasinopoulos

2

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Robert L Medcalf

4

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language of work or name

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publication date

2005

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Nucleic Acids Research

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33

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3

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1010-20

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC549410/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Sequence determinants in human polyadenylation site selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

7 April 2017

Patterns of variant polyadenylation signal usage in human genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

7 April 2017

Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

7 April 2017

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

7 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

7 April 2017

3'-End processing of pre-mRNA in eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

7 April 2017

Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

7 April 2017

G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3'-end formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

The blood coagulation system as a molecular machine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

The intronic prothrombin 19911A&gt;G polymorphism influences splicing efficiency and modulates effects of the 20210G&gt;A polymorphism on mRNA amount and expression in a stable reporter gene assay system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Characterization of specific protein-RNA complexes associated with the coupling of polyadenylation and last-intron removal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Reexamining the polyadenylation signal: were we wrong about AAUAAA?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Identification of alternate polyadenylation sites and analysis of their tissue distribution using EST data.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Recruitment of a basal polyadenylation factor by the upstream sequence element of the human lamin B2 polyadenylation signal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

In silico detection of control signals: mRNA 3'-end-processing sequences in diverse species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Utilization of splicing elements and polyadenylation signal elements in the coupling of polyadenylation and last-intron removal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Transcriptional regulation of the tissue-type plasminogen-activator gene in human endothelial cells: identification of nuclear factors that recognise functional elements in the tissue-type plasminogen-activator gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Transcription and polyadenylation in a short human intergenic region.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Cleavage site determinants in the mammalian polyadenylation signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Effect of RNA secondary structure on polyadenylation site selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

Definition of the upstream efficiency element of the simian virus 40 late polyadenylation signal by using in vitro analyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 September 2017

The prothrombin 3'end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 November 2018

Prothrombin G20210A is a bifunctional gene polymorphism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 November 2018

Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 November 2018

Increased risk for venous thrombosis in carriers of the prothrombin G-->A20210 gene variant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 November 2018

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549410

28 November 2018

Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The G20210A mutation does not affect the stability of prothrombin mRNA in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cleavage/polyadenylation activity triggered by a U-rich motif sequence is differently required depending on the poly(A) site location at either the first or last 3'-terminal exon of the 2'-5' oligo(A) synthetase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upstream elements present in the 3'-untranslated region of collagen genes influence the processing efficiency of overlapping polyadenylation signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro polyadenylation is stimulated by the presence of an upstream intron

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of venous thromboembolism associated with a G to A transition at position 20210 in the 3'-untranslated region of the prothrombin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prothrombin 20210A allele is the most prevalent genetic risk factor for venous thromboembolism in the Spanish population

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of polyadenylation signals in human DNA sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/15718300

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1093/NAR/GKI245

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