(Q24793039)

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Mass spectrometrical analysis of recombinant human growth hormone (Genotropin(R)) reveals amino acid substitutions in 2% of the expressed protein

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scholarly article

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Mass spectrometrical analysis of recombinant human growth hormone (Genotropin(R)) reveals amino acid substitutions in 2% of the expressed protein (English)

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Elisabeth Roitinger

3

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object named as

Gert Lubec

4

1 reference

ORCID Public Data File 2021

author name string

Felix Hepner

1

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Edina Cszasar

2

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publication date

11 February 2005

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Proteome Science

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3

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1

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1

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Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

7 April 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

7 April 2017

Isolated growth hormone deficiency and the GH-1 gene: update 2002

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

7 April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

7 April 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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7 April 2017

Proteomic profiling of human hippocampus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomics

1 reference

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28 September 2017

Prolonged retention after aggregation into secretory granules of human R183H-growth hormone (GH), a mutant that causes autosomal dominant GH deficiency type II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Separation of oxidized and deamidated human growth hormone variants by isocratic reversed-phase high-performance liquid chromatography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Biologically inactive growth hormone caused by an amino acid substitution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Effects of consecutive AGG codons on translation in Escherichia coli, demonstrated with a versatile codon test system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Variants of growth hormone and prolactin and their posttranslational modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Codon--anticodon pairing: the wobble hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

The AGG codon is translated slowly in E. coli even at very low expression levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Translation of the sequence AGG-AGG yields 50% ribosomal frameshift

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Characterisation of a secreted form of recombinant derived human growth hormone, expressed in Escherichia coli cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Growth Hormone Heterogeneity: Genes, Isohormones, Variants, and Binding Proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

Novel in-frame two codon translational hop during synthesis of bovine placental lactogen in a recombinant strain of Escherichia coli

1 reference

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28 September 2017

Editing of errors in selection of amino acids for protein synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 September 2017

22- and 20kDa-human growth hormones bind to different sites within certain cellular receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

30 May 2018

Glycosylated human growth hormone (hGH): a novel 24 kDa hGH-N variant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

30 May 2018

Isolation of Escherichia coli synthesized recombinant eukaryotic proteins that contain epsilon-N-acetyllysine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

30 May 2018

Methionine oxidation in human growth hormone and human chorionic somatomammotropin. Effects on receptor binding and biological activities.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

30 May 2018

Separation and identification of growth hormone variants with high performance liquid chromatography techniques.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

30 May 2018

Low-usage codons in Escherichia coli, yeast, fruit fly and primates

1 reference

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30 May 2018

A novel dysfunctional growth hormone variant (Ile179Met) exhibits a decreased ability to activate the extracellular signal-regulated kinase pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 November 2018

Growth hormone antibodies formation in patients treated with recombinant human growth hormone

1 reference

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28 November 2018

Aplastic Anemia during Growth Hormone (GH) Treatment in a Girl with Idiopathic GH-Deficiency

1 reference

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28 November 2018

Reduced insulin sensitivity during growth hormone therapy for short children born small for gestational age.

1 reference

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28 November 2018

Reduction of actin-related protein complex 2/3 in fetal Down syndrome brain.

1 reference

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28 November 2018

A 12-kilodalton N-glycosylated growth hormone-related peptide is present in human pituitary extracts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=549540

28 November 2018

The 20-kD human growth hormone reduces body fat by increasing lipolysis and decreasing lipoprotein lipase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15707495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth hormone therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15707495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current clinical trials with authentic recombinant human growth hormone in Japan

1 reference

https://pubmed.ncbi.nlm.nih.gov/15707495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of a structural and a functional epitope

1 reference

https://pubmed.ncbi.nlm.nih.gov/15707495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-glycosylated variants of growth hormone in human pituitary extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15707495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Five-year follow-up of growth hormone antibodies in growth hormone deficient children treated with recombinant human growth hormone

1 reference

https://pubmed.ncbi.nlm.nih.gov/15707495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of lysine residues in the binding of hGH and bGH to somatotropic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15707495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1186/1477-5956-3-1

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