(Q24814716)

4 July 2017

Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo (English)

1 reference

4 July 2017

5

Ole Petter Ottersen

1 reference

4 July 2017

6

Arne Klungland

1 reference

4 July 2017

Torgeir Holen

1

1 reference

4 July 2017

Svein Erik Moe

series ordinal

2

1 reference

4 July 2017

Jan Gunnar Sørbø

series ordinal

3

1 reference

4 July 2017

Trine J Meza

series ordinal

4

1 reference

4 July 2017

language of work or name

English

0 references

publication date

19 August 2005

1 reference

4 July 2017

7

1 reference

based on heuristic

inferred from page(s)

published in

Nucleic Acids Research

1 reference

4 July 2017

33

1 reference

4 July 2017

4704-4710

1 reference

4 July 2017

15

1 reference

describes a project that uses

4 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1188085/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

A computational study of off-target effects of RNA interference

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Functional siRNAs and miRNAs Exhibit Strand Bias

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Asymmetry in the assembly of the RNAi enzyme complex

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Specificity of microRNA target selection in translational repression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Rational siRNA design for RNA interference

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Expression profiling reveals off-target gene regulation by RNAi

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Unravelling the general properties of siRNAs: strength in numbers and lessons from the past

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Kinetic analysis of the RNAi enzyme complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Many commonly used siRNAs risk off-target activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

RISC is a 5' phosphomonoester-producing RNA endonuclease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

The molecular basis of water transport in the brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Specificity of short interfering RNA determined through gene expression signatures

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Genomewide view of gene silencing by small interfering RNAs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Tolerance for mutations and chemical modifications in a siRNA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Mammalian RNAi for the masses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Mechanisms of RNAi: mRNA cleavage fragments may indicate stalled RISC.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

A comparison of siRNA efficacy predictors.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1188085

Mechanism and binding sites in the ribonuclease reaction. II. Kinetic studies on the first step of the reaction

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16113241

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKI785

1 reference

4 July 2017

1 reference

4 July 2017

1 reference