(Q24815571)

English

Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 July 2017

Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

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Matthew D. Krasowski

object named as

Matthew D Krasowski

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author name string

Kazuto Yasuda

2

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

Lee R Hagey

3

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Europe PubMed Central

PubMed publication ID

5 July 2017

Erin G Schuetz

4

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Europe PubMed Central

PubMed publication ID

5 July 2017

language of work or name

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publication date

30 September 2005

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Europe PubMed Central

PubMed publication ID

5 July 2017

Nuclear receptor

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Europe PubMed Central

PubMed publication ID

5 July 2017

3

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Europe PubMed Central

PubMed publication ID

5 July 2017

1

0 references

2

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution.

1 reference

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Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

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2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

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Vitamin D receptor as an intestinal bile acid sensor

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Genomewide comparison of DNA sequences between humans and chimpanzees

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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Cloning and expression of full-length cDNA encoding human vitamin D receptor

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7 April 2017

Noncalcemic Actions of Vitamin D Receptor Ligands

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7 April 2017

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

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Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands

1 reference

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PAML: a program package for phylogenetic analysis by maximum likelihood

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The nuclear receptor superfamily: the second decade

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7 April 2017

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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7 April 2017

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

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7 April 2017

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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Statistical methods for detecting molecular adaptation

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

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7 April 2017

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

1 reference

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A unified nomenclature system for the nuclear receptor superfamily

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Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element

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Evolution and diversification of the nuclear receptor superfamily

1 reference

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

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Evolution of the nuclear receptor superfamily: early diversification from an ancestral orphan receptor

1 reference

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An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

1 reference

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Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts

1 reference

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1 reference

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Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

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Stay tuned to PXR: an orphan actor that may not be D-structive only to bone

1 reference

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Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism

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Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease

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Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling

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Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

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Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity.

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Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

1 reference

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28 September 2017

Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans

1 reference

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Orphan nuclear receptors: the exotics of xenobiotics.

1 reference

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Binding of ligands and activation of transcription by nuclear receptors.

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Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

1 reference

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28 September 2017

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

1 reference

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Ligand binding and nuclear receptor evolution

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BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites.

1 reference

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28 September 2017

Transcription factors 3: nuclear receptors.

1 reference

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1 reference

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31 May 2018

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

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31 May 2018

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31 May 2018

Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish

1 reference

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28 November 2018

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer

1 reference

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28 November 2018

The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Evolutionary genomics of nuclear receptors: from twenty-five ancestral genes to derived endocrine systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Cloning and developmental expression of five estrogen-receptor related genes in the zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Physicochemical and physiological properties of 5alpha-cyprinol sulfate, the toxic bile salt of cyprinid fish

1 reference

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28 November 2018

Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors

1 reference

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28 November 2018

Accuracy and power of bayes prediction of amino acid sites under positive selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

1 reference

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28 November 2018

Expression pattern of BXR suggests a role for benzoate ligand-mediated signalling in hatching gland function.

1 reference

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28 November 2018

The nuclear receptor ligand-binding domain: structure and function

1 reference

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28 November 2018

Large-scale search for genes on which positive selection may operate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1262763

28 November 2018

Eleven Novel Single Nucleotide Polymorphisms in the NRH2 (PXR) Gene, Pour of which Induce Non-synonymous Amino Acid Alterations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16197547

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent false detection of positive selection by the likelihood method with branch-site models

1 reference

https://pubmed.ncbi.nlm.nih.gov/16197547

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/16197547

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1478-1336-3-2

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

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0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 July 2017

ResearchGate publication ID

0 references

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