(Q25255833)

6 July 2017

title

mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity (English)

1 reference

6 July 2017

5

Caroline A Austin

1 reference

6 July 2017

Kathryn L Gilroy

1

1 reference

6 July 2017

Chrysoula Leontiou

series ordinal

2

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6 July 2017

Kay Padget

series ordinal

3

1 reference

6 July 2017

Jeremy H Lakey

series ordinal

4

1 reference

6 July 2017

language of work or name

English

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publication date

20 March 2006

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6 July 2017

published in

Nucleic Acids Research

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6 July 2017

volume

34

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6 July 2017

issue

5

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6 July 2017

page(s)

1597-1607

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Mutagenesis of E477 or K505 in the B' domain of human topoisomerase II beta increases the requirement for magnesium ions during strand passage

6 July 2017

cites work

1 reference

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Recent advances in understanding structure–function relationships in the type II topoisomerase mechanism

7 April 2017

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Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

7 April 2017

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Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands

7 April 2017

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Structure and mechanism of DNA topoisomerase II

7 April 2017

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Phase II study of XR5000 (DACA), an inhibitor of topoisomerase I and II, administered as a 120-h infusion in patients with advanced ovarian cancer

7 April 2017

1 reference

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The ATPase reaction cycle of yeast DNA topoisomerase II. Slow rates of ATP resynthesis and P(i) release

7 April 2017

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Mutations at arg486 and glu571 in human topoisomerase IIalpha confer resistance to amsacrine: relevance for antitumor drug resistance in human cells

7 April 2017

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Mutation E522K in human DNA topoisomerase IIbeta confers resistance to methyl N-(4'-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4'-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide

7 April 2017

1 reference

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Functional dissection of the C-terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani

28 September 2017

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Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity

28 September 2017

1 reference

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A human topoisomerase II alpha heterodimer with only one ATP binding site can go through successive catalytic cycles.

28 September 2017

1 reference

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Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells

28 September 2017

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Locking the ATP-operated clamp of DNA gyrase: probing the mechanism of strand passage

28 September 2017

1 reference

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Two differentially spliced forms of topoisomerase IIalpha and beta mRNAs are conserved between birds and humans.

28 September 2017

1 reference

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Topoisomerase II drives DNA transport by hydrolyzing one ATP

28 September 2017

1 reference

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On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

The role of DNA topoisomerases II in drug resistance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Identifying the catalytic residue of the ATPase reaction of DNA gyrase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Treatment of chronic myelogenous leukemia in blast crisis and in accelerated phase with high- or intermediate-dose cytosine arabinoside and amsacrine

28 September 2017

1 reference

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Using yeast to study resistance to topoisomerase II-targeting drugs.

28 September 2017

1 reference

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Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Functional expression of human topoisomerase II alpha in yeast: mutations at amino acids 450 or 803 of topoisomerase II alpha result in enzymes that can confer resistance to anti-topoisomerase II agents.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Bipartite nuclear localization signals in the C terminus of human topoisomerase II alpha.

31 May 2018

1 reference

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The C-terminal domain of Saccharomyces cerevisiae DNA topoisomerase II.

31 May 2018

1 reference

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Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

The transducer domain is important for clamp operation in human DNA topoisomerase IIalpha

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Analysis of bisdioxopiperazine dexrazoxane binding to human DNA topoisomerase II alpha: decreased binding as a mechanism of drug resistance

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

A mutant yeast topoisomerase II (top2G437S) with differential sensitivity to anticancer drugs in the presence and absence of ATP.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Clinical resistance to topoisomerase-targeted drugs.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Drug resistance to topoisomerase II inhibitors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1405819

Pre-steady-state analysis of ATP hydrolysis by Saccharomyces cerevisiae DNA topoisomerase II. 1. A DNA-dependent burst in ATP hydrolysis

28 November 2018

1 reference

12 December 2020

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

1 reference

12 December 2020

The N-Terminal Domain of Human Topoisomerase IIα Is a DNA-Dependent ATPase†

1 reference

12 December 2020

Catalysis of ATP hydrolysis by two NH(2)-terminal fragments of yeast DNA topoisomerase II

1 reference

12 December 2020

Communication between the ATPase and cleavage/religation domains of human topoisomerase IIalpha

1 reference

12 December 2020

Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIalpha

1 reference

12 December 2020

The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases

1 reference

12 December 2020

Phosphorylation of the C-terminal domain of yeast topoisomerase II by casein kinase II affects DNA-protein interaction

1 reference

12 December 2020

Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta

1 reference

12 December 2020

From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): selectivity for topoisomerases I and II among acridine derivatives

1 reference

12 December 2020

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta

1 reference

12 December 2020

Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2 beta construct allows the study of topoisomerase II beta inhibitors in yeast

1 reference

12 December 2020

Footprinting of yeast DNA topoisomerase II lysyl side chains involved in substrate binding and interdomainal interactions

1 reference

12 December 2020

The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IIα

1 reference

12 December 2020

Pre-steady-state analysis of ATP hydrolysis by Saccharomyces cerevisiae DNA topoisomerase II. 2. Kinetic mechanism for the sequential hydrolysis of two ATP

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKL057

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6 July 2017

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6 July 2017

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