(Q26314693)

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Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention

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22 June 2019

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3 November 2019

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15 September 2020

27 October 2020

5 November 2020

22 August 2022

22 October 2022

Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention (English)

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viral genome replication

reason for deprecated rank

cannot be confirmed by other sources

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15 September 2020

5 November 2020

1 reference

based on heuristic

inferred from title

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3 November 2019

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23 December 2019

host microbial interaction

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27 July 2020

antiviral agent

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27 October 2020

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dengue virus protein NS4B

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based on heuristic

inferred from abstract

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publication date

July 2015

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1 July 2015

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22 June 2019

20 June 2019

3 November 2019

23 December 2019

27 July 2020

15 September 2020

27 October 2020

5 November 2020

22 August 2022

22 October 2022

Reviews in Medical Virology

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22 June 2019

20 June 2019

3 November 2019

23 December 2019

27 July 2020

15 September 2020

27 October 2020

5 November 2020

22 August 2022

22 October 2022

25

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205-23

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copyright license

Creative Commons Attribution

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22 June 2019

20 June 2019

3 November 2019

23 December 2019

27 July 2020

15 September 2020

27 October 2020

5 November 2020

22 August 2022

22 October 2022

copyright status

0 references

Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention

0 references

Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy

1 reference

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The global distribution and burden of dengue

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DENV inhibits type I IFN production in infected cells by cleaving human STING

1 reference

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A physical interaction network of dengue virus and human proteins

1 reference

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A diverse range of gene products are effectors of the type I interferon antiviral response

1 reference

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Molecular targets for flavivirus drug discovery

1 reference

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A Dengue Fever Viremia Model in Mice Shows Reduction in Viral Replication and Suppression of the Inflammatory Response after Treatment with Antiviral Drugs

1 reference

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Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo

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7 April 2017

Molecular biology of flaviviruses

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7 April 2017

Inhibition of interferon signaling by dengue virus

1 reference

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Inhibition of Stat1-mediated gene activation by PIAS1

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Estimated global incidence of Japanese encephalitis: a systematic review

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Japanese encephalitis: the virus and vaccines

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Identification of Inhibitors of Yellow Fever Virus Replication Using a Replicon-Based High-Throughput Assay

1 reference

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1 reference

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Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Flaviviruses

1 reference

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Differential Effects of Mutations in NS4B on West Nile Virus Replication and Inhibition of Interferon Signaling

1 reference

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Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus

1 reference

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7 April 2017

A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis

1 reference

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1 reference

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Palmitoylation and Polymerization of Hepatitis C Virus NS4B Protein

1 reference

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Inhibition of Alpha/Beta Interferon Signaling by the NS4B Protein of Flaviviruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

7 April 2017

Molecular characterization of a hamster viscerotropic strain of yellow fever virus

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

7 April 2017

Antiviral effects of an iminosugar derivative on flavivirus infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

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West Nile virus/dengue type 4 virus chimeras that are reduced in neurovirulence and peripheral virulence without loss of immunogenicity or protective efficacy

1 reference

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Alpha-glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum

1 reference

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Efficient trans-complementation of the flavivirus kunjin NS5 protein but not of the NS1 protein requires its coexpression with other components of the viral replicase

1 reference

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Deletion analysis of dengue virus type 4 nonstructural protein NS2B: identification of a domain required for NS2B-NS3 protease activity

1 reference

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RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria

1 reference

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The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

1 reference

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Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen

1 reference

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SUMO Ubc9 enzyme as a viral target

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

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Identification of new protein interactions between dengue fever virus and its hosts, human and mosquito

1 reference

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

1 reference

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Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity

1 reference

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

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1 reference

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1 reference

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RNA interference screen for human genes associated with West Nile virus infection

1 reference

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Mapping the Interactions between the NS4B and NS3 proteins of dengue virus

1 reference

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1 reference

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A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.

1 reference

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Flavivirus RNAi suppression: decoding non-coding RNA.

1 reference

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SUMOylation proteins in breast cancer

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Sumoylation at the host-pathogen interface

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Hepatitis C virus proteins: from structure to function

1 reference

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1 reference

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28 September 2017

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1 reference

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Experimental therapies for yellow fever

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28 September 2017

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1 reference

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28 September 2017

Herpes simplex virus 1 ubiquitin ligase ICP0 interacts with PML isoform I and induces its SUMO-independent degradation.

1 reference

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1 reference

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28 September 2017

NS4A and NS4B proteins from dengue virus: membranotropic regions

1 reference

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28 September 2017

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1 reference

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1 reference

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1 reference

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28 September 2017

Mutational analysis of the West Nile virus NS4B protein

1 reference

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West nile virus infections suppress early viral RNA synthesis and avoid inducing the cell stress granule response

1 reference

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1 reference

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28 September 2017

Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi

1 reference

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1 reference

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28 September 2017

Inhibition of dengue virus by targeting viral NS4B protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Development and characterization of a stable luciferase dengue virus for high-throughput screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Identification of viral suppressors of RNAi by a reporter assay in Drosophila S2 cell culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Dengue virus modulates the unfolded protein response in a time-dependent manner

1 reference

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28 September 2017

West Nile virus and its emergence in the United States of America

1 reference

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28 September 2017

Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

RNA-based antiviral immunity

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Subversion of interferon by dengue virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Targeting the ubiquitin system in cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

The flavivirus polymerase as a target for drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Modification of intracellular membrane structures for virus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

The type 2 dengue virus envelope protein interacts with small ubiquitin-like modifier-1 (SUMO-1) conjugating enzyme 9 (Ubc9).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Mutations which enhance the replication of dengue virus type 4 and an antigenic chimeric dengue virus type 2/4 vaccine candidate in Vero cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

De novo synthesis of RNA by the dengue virus RNA-dependent RNA polymerase exhibits temperature dependence at the initiation but not elongation phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

The Ebola virus VP35 protein functions as a type I IFN antagonist.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Perspectives for the treatment of infections with Flaviviridae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Molecular and biological changes associated with HeLa cell attenuation of wild-type yellow fever virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Proteins C and NS4B of the flavivirus Kunjin translocate independently into the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Nuclear export signals and the fast track to the cytoplasm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 September 2017

Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

31 May 2018

Cytokine-induced paracrystals prolong the activity of signal transducers and activators of transcription (STAT) and provide a model for the regulation of protein solubility by small ubiquitin-like modifier (SUMO).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

31 May 2018

West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

31 May 2018

Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

31 May 2018

The carboxy-terminal part of the NS 3 protein of the West Nile Flavivirus can be isolated as a soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

31 May 2018

West Nile virus.

1 reference

https://api.crossref.org/works/10.1002%2FRMV.1835

21 January 2018

Expression and purification of enzymatically active recombinant RNA-dependent RNA polymerase (NS5) of the flavivirus Kunjin

1 reference

https://api.crossref.org/works/10.1002%2FRMV.1835

21 January 2018

Dimerization of flavivirus NS4B protein

1 reference

https://api.crossref.org/works/10.1002%2FRMV.1835

21 January 2018

Tomato bushy stunt virus co-opts the RNA-binding function of a host metabolic enzyme for viral genomic RNA synthesis

1 reference

https://api.crossref.org/works/10.1002%2FRMV.1835

21 January 2018

Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4864441

28 November 2018

Vaccines and vaccination against yellow fever. WHO position paper -- June 2013

1 reference

https://pubmed.ncbi.nlm.nih.gov/25828437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmaceutical approval update

1 reference

https://pubmed.ncbi.nlm.nih.gov/25828437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/RMV.1835

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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