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TIM-3 Regulates Distinct Functions in Macrophages
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Europe PubMed Central
title
TIM-3 Regulates Distinct Functions in Macrophages
(English)
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main subject
macrophage
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author name string
Ranferi Ocaña-Guzman
series ordinal
1
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Luis Torre-Bouscoulet
series ordinal
2
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Isabel Sada-Ovalle
series ordinal
3
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language of work or name
English
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publication date
2016
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published in
Frontiers in Immunology
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stated in
Crossref
volume
7
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page(s)
229
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cites work
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T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells
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T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface
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7 April 2017
Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
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7 April 2017
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells
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PubMed Central
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7 April 2017
Tim3 binding to galectin-9 stimulates antimicrobial immunity
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PubMed Central
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7 April 2017
Lack of TIM-3 immunoregulation in multiple sclerosis
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PubMed Central
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7 April 2017
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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7 April 2017
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
1 reference
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PubMed Central
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7 April 2017
Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway
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PubMed Central
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7 April 2017
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
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PubMed Central
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7 April 2017
Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
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7 April 2017
Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.
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PubMed Central
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28 September 2017
uPAR induces expression of transforming growth factor β and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages.
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28 September 2017
Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancer
1 reference
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PubMed Central
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28 September 2017
Tim-3 is differently expressed in genetically susceptible C57BL/6 and resistant BALB/c mice during oral infection with Toxoplasma gondii.
1 reference
stated in
PubMed Central
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28 September 2017
TIM-3 expression in human osteosarcoma: Correlation with the expression of epithelial-mesenchymal transition-specific biomarkers
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PubMed Central
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28 September 2017
Cis association of galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling
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PubMed Central
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28 September 2017
IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation
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28 September 2017
T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 September 2017
Tim-3 expression in cervical cancer promotes tumor metastasis
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PubMed Central
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28 September 2017
The Tim3-galectin 9 pathway induces antibacterial activity in human macrophages infected with Mycobacterium tuberculosis
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28 September 2017
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
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28 September 2017
Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophages
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28 September 2017
Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.
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28 September 2017
Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection
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Tim-3 expression on peripheral T cell subsets correlates with disease progression in hepatitis B infection
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28 September 2017
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
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28 September 2017
T cell Ig and mucin domain proteins and immunity
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28 September 2017
Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
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28 September 2017
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 September 2017
Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival
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28 September 2017
Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 September 2017
T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis
1 reference
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PubMed Central
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28 September 2017
The final step in programmed cell death: phagocytes carry apoptotic cells to the grave
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PubMed Central
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28 September 2017
The TIM gene family: emerging roles in immunity and disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 September 2017
Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 September 2017
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 September 2017
Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 September 2017
Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L.
1 reference
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PubMed Central
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31 May 2018
Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes
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PubMed Central
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31 May 2018
The Binding Properties of Glycosylated and Non-Glycosylated Tim-3 Molecules on CD4CD25 T Cells.
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31 May 2018
Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury.
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21 January 2018
Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems.
1 reference
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Crossref
reference URL
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21 January 2018
Blockade of Tim-3 signaling restores the virus-specific CD8⁺ T-cell response in patients with chronic hepatitis B.
1 reference
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Crossref
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21 January 2018
Ectopic expression of TIM-3 in lung cancers: a potential independent prognostic factor for patients with NSCLC.
1 reference
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Crossref
reference URL
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21 January 2018
Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904032
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28 November 2018
Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27379093
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Galectin-9 suppresses Th17 cell development in an IL-2-dependent but Tim-3-independent manner
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27379093
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FIMMU.2016.00229
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
846399
OpenCitations bibliographic resource ID
846399
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
846399
PMCID
4904032
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
846399
PubMed ID
27379093
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
846399
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