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RAS proto-oncogene in medullary thyroid carcinoma
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title
RAS proto-oncogene in medullary thyroid carcinoma
(English)
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main subject
thyroid carcinoma
1 reference
based on heuristic
inferred from title
author
Margarida M Moura
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
Branca M. Cavaco
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
Valeriano Leite
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
author name string
Margarida M Moura
series ordinal
1
0 references
Branca M Cavaco
series ordinal
2
0 references
Valeriano Leite
series ordinal
3
0 references
language of work or name
English
0 references
publication date
October 2015
0 references
published in
Endocrine-Related Cancer
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
volume
22
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
issue
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
page(s)
R235-52
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
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The PDCD4/miR-21 pathway in medullary thyroid carcinoma.
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7 January 2021
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Somatic mutations in the RET proto-oncogene in sporadic medullary thyroid carcinomas
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Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC.
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Chromosome 10 and RET gene copy number alterations in hereditary and sporadic Medullary Thyroid Carcinoma
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Epigenetic-related gene expression profile in medullary thyroid cancer revealed the overexpression of the histone methyltransferases EZH2 and SMYD3 in aggressive tumours
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Risk estimation and screening in families of patients with medullary thyroid carcinoma
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AN UNIDENTIFIED VIRUS WHICH CAUSES THE RAPID PRODUCTION OF TUMOURS IN MICE.
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Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells
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7 January 2021
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A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
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Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas
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based on heuristic
inferred from DOI database lookup
Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma
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Crossref
reference URL
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based on heuristic
inferred from DOI database lookup
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
C-Cell Hyperplasia Preceding Medullary Thyroid Carcinoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Lessons Learned from the Management of a Rare Genetic Cancer
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
1 reference
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Crossref
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro isolation of stable rat sarcoma viruses
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7 January 2021
based on heuristic
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Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells
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reference URL
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7 January 2021
based on heuristic
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1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells
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7 January 2021
based on heuristic
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RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors
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Medullary thyroid cancer: management guidelines of the American Thyroid Association
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MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome
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7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence of a low prevalence of RAS mutations in a large medullary thyroid cancer series.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
VEGF, VEGFR3, and PDGFRB protein expression is influenced by RAS mutations in medullary thyroid carcinoma.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
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Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.
1 reference
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7 January 2021
based on heuristic
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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
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An update on clinical trials of targeted therapies in thyroid cancer
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7 January 2021
based on heuristic
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Inactivation of the p53 gene is not required for tumorigenesis of medullary thyroid carcinoma or pheochromocytoma
1 reference
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Crossref
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC).
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Programmed cell death 4 nuclear loss and miR-21 or activated Akt overexpression in esophageal squamous cell carcinogenesis.
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7 January 2021
based on heuristic
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Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Histogenesis of medullary carcinoma of the thyroid
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7 January 2021
based on heuristic
inferred from DOI database lookup
Akt phosphorylates and regulates Pdcd4 tumor suppressor protein
1 reference
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Genomic and biological characterization of exon 4 KRAS mutations in human cancer
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
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A comprehensive survey of Ras mutations in cancer
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
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Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
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MicroRNA profiling of sporadic and hereditary medullary thyroid cancer identifies predictors of nodal metastasis, prognosis, and potential therapeutic targets
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases.
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
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Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib
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https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of K-RAS by co-mutation of codons 19 and 20 is transforming
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
RET proto-oncogene in the development of human cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Medullary thyroid cancer: options for systemic therapy of metastatic disease?
1 reference
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reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific pattern of RAS oncogene mutations in follicular thyroid tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
BRAF T1796A transversion mutation in various thyroid neoplasms.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
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7 January 2021
based on heuristic
inferred from DOI database lookup
Uncommon Mutation, but Common Amplifications, of thePIK3CAGene in Thyroid Tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utility
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian target of rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle deregulation and TP53 and RAS mutations are major events in poorly differentiated and undifferentiated thyroid carcinomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Farnesyl transferase inhibitors in clinical development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
mTOR activation in medullary thyroid carcinoma with RAS mutation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of RET mutations on the expression of tyrosine kinases in medullary thyroid carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRAF and endocrine tumors: mutations are frequent in papillary thyroid carcinomas, rare in endocrine tumors of the gastrointestinal tract and not detected in other endocrine tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRAF mutation in thyroid cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Medullary thyroid carcinoma: The third most common thyroid cancer reviewed
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1530%2FERC-15-0070
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1530/ERC-15-0070
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
PubMed publication ID
26285815
1 reference
stated in
Europe PubMed Central
PubMed publication ID
26285815
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26285815%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 June 2020
ResearchGate publication ID
281195479
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