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Proteins regulating Ras and its relatives
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instance of
scholarly article
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Europe PubMed Central
title
Proteins regulating Ras and its relatives
(English)
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author name string
M S Boguski
series ordinal
1
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F McCormick
series ordinal
2
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language of work or name
English
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publication date
16 December 1993
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published in
Nature
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volume
366
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page(s)
643-54
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issue
6456
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cites work
ras genes
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The GTPase superfamily: conserved structure and molecular mechanism
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The GTPase superfamily: a conserved switch for diverse cell functions
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Regulators and Effectors of ras Proteins
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The ras superfamily of GTP-binding proteins: guidelines on nomenclature
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Bcl-2 associates with the ras-related protein R-ras p23
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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
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The biochemical basis of the NADPH oxidase of phagocytes.
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Checkpoint controls that couple mitosis to completion of DNA replication
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ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes
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Intravesicular acidification correlates with binding of ADP-ribosylation factor to microsomal membranes
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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
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The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein.
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Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins
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The Saccharomyces cerevisiae CDC25 gene product binds specifically to catalytically inactive ras proteins in vivo
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A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.
1 reference
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RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP
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The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.
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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
1 reference
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Crossref
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7 January 2021
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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
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Crossref
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7 January 2021
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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.
1 reference
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7 January 2021
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Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes
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7 January 2021
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The function of GRB2 in linking the insulin receptor to Ras signaling pathways
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Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras
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Development of cell polarity in budding yeast
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7 January 2021
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BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast
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7 January 2021
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Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant.
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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
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7 January 2021
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Complex formation between RAS and RAF and other protein kinases
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Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
1 reference
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7 January 2021
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Mammalian Ras interacts directly with the serine/threonine kinase Raf
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Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product
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Molecular cloning and expression of the major protein kinase C substrate of platelets
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7 January 2021
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Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets
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7 January 2021
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7 January 2021
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1 reference
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7 January 2021
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Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene
1 reference
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Characterization of a guanine nucleotide-releasing factor and a GTPase-activating protein that are specific for the ras-related protein p25rab3A
1 reference
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DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function
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A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4.
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Crossref
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Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Tissue distribution of smg p25A, a ras p21-like GTP-binding protein, studied by use of a specific monoclonal antibody.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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A Drosophila homolog of bovine smg p25a GDP dissociation inhibitor undergoes a shift in isoelectric point in the developmental mutant quartet
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Crossref
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7 January 2021
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MRS6--yeast homologue of the choroideraemia gene.
1 reference
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Crossref
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7 January 2021
based on heuristic
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Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus
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7 January 2021
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A novel role for RhoGDI as an inhibitor of GAP proteins
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7 January 2021
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1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
ras and GAP--who's controlling whom?
1 reference
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7 January 2021
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SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins
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7 January 2021
based on heuristic
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A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP
1 reference
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7 January 2021
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Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity
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7 January 2021
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GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the SH3 domain of GAP as an essential sequence for Ras-GAP-mediated signaling
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
GAPs in understanding Ras
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
1 reference
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7 January 2021
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Neurofibromatosis type 1 gene mutations in neuroblastoma.
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7 January 2021
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Somatic mutations in the neurofibromatosis 1 gene in human tumors
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7 January 2021
based on heuristic
inferred from DOI database lookup
A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis
1 reference
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7 January 2021
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Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene
1 reference
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7 January 2021
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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differential regulation in the avian song control circuit of an mRNA predicting a highly conserved protein related to protein kinase C and the bcr oncogene
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
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Identification and partial purification of GTPase-activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
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7 January 2021
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Protein prenylation: genes, enzymes, targets, and functions.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
RAM2, an essential gene of yeast, and RAM1 encode the two polypeptide components of the farnesyltransferase that prenylates a-factor and Ras proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor.
1 reference
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dependence of Ypt1 and Sec4 membrane attachment on Bet2.
1 reference
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase
1 reference
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Association between GTPase activators for Rho and Ras families.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae
1 reference
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F366643A0
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7 January 2021
based on heuristic
inferred from DOI database lookup
PROSITE: a dictionary of sites and patterns in proteins
1 reference
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7 January 2021
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The SWISS-PROT protein sequence data bank.
1 reference
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7 January 2021
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inferred from DOI database lookup
dbEST--database for "expressed sequence tags"
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F366643A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A workbench for multiple alignment construction and analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F366643A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proto-vav and gene expression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F366643A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F366643A0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/366643A0
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4805957
Dimensions Publication ID
1005902014
0 references
OpenCitations bibliographic resource ID
4805957
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4805957
PubMed ID
8259209
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4805957
ResearchGate publication ID
14940502
0 references
Springer Nature article ID
10.1038/366643a0
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