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PI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical application
scientific article (publication date: 2015)
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
review article
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stated in
Europe PubMed Central
title
PI3K/Akt/mTOR signaling pathway in cancer stem cells: from basic research to clinical application
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
main subject
neoplastic stem cells
1 reference
based on heuristic
inferred from title
author name string
Pu Xia
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
Xiao-Yan Xu
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
language of work or name
English
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publication date
15 April 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
published in
American Journal of Cancer Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
volume
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
page(s)
1602-1609
1 reference
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
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PI3K/mTOR pathway inhibitors sensitize chronic myeloid leukemia stem cells to nilotinib and restore the response of progenitors to nilotinib in the presence of stem cell factor
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Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation
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NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro
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Rapamycin inhibits FBXW7 loss-induced epithelial-mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells
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Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt
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Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells
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Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment.
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28 September 2017
Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
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28 September 2017
Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo
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28 September 2017
The quinoline imidoselenocarbamate EI201 blocks the AKT/mTOR pathway and targets cancer stem cells leading to a strong antitumor activity.
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28 September 2017
Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells
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28 September 2017
Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations
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28 September 2017
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28 September 2017
Combination of salinomycin and gemcitabine eliminates pancreatic cancer cells
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28 September 2017
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28 September 2017
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28 September 2017
Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
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Drug discovery approaches to target Wnt signaling in cancer stem cells
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28 September 2017
Salinomycin selectively targets 'CD133+' cell subpopulations and decreases malignant traits in colorectal cancer lines
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Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells
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Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.
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28 September 2017
Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells
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28 September 2017
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28 September 2017
mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells
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28 September 2017
ALDH1 as a functional marker of cancer stem and progenitor cells
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28 September 2017
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
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PubMed Central
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28 September 2017
Drug therapy for acute myeloid leukemia
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28 September 2017
Rottlerin, a novel protein kinase inhibitor
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28 September 2017
Regulatory role of miR-142-3p on the functional hepatic cancer stem cell marker CD133.
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31 May 2018
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
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31 May 2018
The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance
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28 November 2018
Efficacy of rapamycin against glioblastoma cancer stem cells.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497429
retrieved
28 November 2018
Everolimus in combination with letrozole inhibit human breast cancer MCF-7/Aro stem cells via PI3K/mTOR pathway: an experimental study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497429
retrieved
28 November 2018
Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497429
retrieved
28 November 2018
PI-103 sensitizes acute myeloid leukemia stem cells to daunorubicin-induced cytotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497429
retrieved
28 November 2018
Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497429
retrieved
28 November 2018
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497429
retrieved
28 November 2018
PIK3CA is implicated as an oncogene in ovarian cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497429
retrieved
28 November 2018
Temsirolimus for advanced renal cell carcinoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26175931
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/26175931
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
OpenCitations bibliographic resource ID
997510
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
997510
PMC publication ID
4497429
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
997510
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
PubMed publication ID
26175931
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
997510
stated in
Europe PubMed Central
PMC publication ID
4497429
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26175931%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 February 2020
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