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Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
scientific article published on November 2013
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scholarly article
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Europe PubMed Central
PMC publication ID
3875761
retrieved
8 September 2017
title
Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1.
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
retrieved
8 September 2017
main subject
colon cancer
1 reference
based on heuristic
inferred from title
author
Maria Giovanna Francipane
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
author name string
Eric Lagasse
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
language of work or name
English
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publication date
1 November 2013
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stated in
Europe PubMed Central
PMC publication ID
3875761
retrieved
8 September 2017
published in
Oncotarget
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stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
volume
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
issue
11
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
page(s)
1948-1962
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
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Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations
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The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer
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mTOR inhibitors in renal cell carcinoma
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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
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mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells
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9 September 2017
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9 September 2017
TOR complex 2: a signaling pathway of its own.
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9 September 2017
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.
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9 September 2017
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
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9 September 2017
Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation
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Nuclear signalling by tumour-associated antigen EpCAM
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9 September 2017
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
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9 September 2017
Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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A stochastic model for cancer stem cell origin in metastatic colon cancer
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
A novel role for villin in intestinal epithelial cell survival and homeostasis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Phenotypic characterization of human colorectal cancer stem cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Identification and expansion of human colon-cancer-initiating cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Mammary stem cells and mammopoiesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
9 September 2017
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
9 September 2017
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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9 September 2017
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
14 September 2017
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
14 September 2017
Expression of Ep-CAM shifts the state of cadherin-mediated adhesions from strong to weak
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
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14 September 2017
Significance of mTOR signaling and its inhibitor against cancer stem-like cells in colorectal cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
21 August 2018
PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
21 August 2018
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
21 August 2018
mTOR signaling pathway is a target for the treatment of colorectal cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875761
retrieved
21 August 2018
Loss of standard type of CD44 expression in invaded area as a good indicator of lymph-node metastasis in colorectal carcinoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24185040
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.18632/ONCOTARGET.1310
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
PMC publication ID
3875761
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
PubMed publication ID
24185040
1 reference
stated in
Europe PubMed Central
PMC publication ID
3875761
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24185040%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 June 2020
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