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Why does the bone marrow fail in Fanconi anemia?
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PubMed
title
Why does the bone marrow fail in Fanconi anemia?
(English)
1 reference
stated in
PubMed
main subject
bone marrow
1 reference
based on heuristic
inferred from title
author name string
J. I. Garaycoechea
series ordinal
1
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stated in
Crossref
K. J. Patel
series ordinal
2
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stated in
Crossref
language of work or name
English
1 reference
stated in
PubMed
publication date
2 January 2014
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stated in
PubMed
published in
Blood
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stated in
PubMed
volume
123
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stated in
PubMed
issue
1
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stated in
PubMed
page(s)
26-34
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PubMed
cites work
Basal metabolic rates in mammals: taxonomic differences in the allometry of BMR and body mass.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
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inferred from DOI database lookup
Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of replication-coupled DNA interstrand crosslink repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The origin and evolution of mutations in acute myeloid leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Localization-dependent and -independent roles of SLX4 in regulating telomeres
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
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DNA repair is crucial for maintaining hematopoietic stem cell function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fanconi anemia and its diagnosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fancd2 and p21 function independently in maintaining the size of hematopoietic stem and progenitor cell pool in mice.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
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inferred from DOI database lookup
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fanconi anemia: myelodysplasia as a predictor of outcome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
[13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of DNA adducts of acetaldehyde.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Susceptibility of Fanconi's anaemia fibroblasts to chromosome damage by carcinogens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of cDNAs for Fanconi's anaemia by functional complementation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of the SLX4 gene in Fanconi anemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
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inferred from DOI database lookup
Guido Fanconi (1892-1979): a jack of all trades.
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Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response
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stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stem cell collection and gene transfer in Fanconi anemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Fanconi anemia polypeptide FACC is localized to the cytoplasm
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of Fanconi anemia C protein to the cytoplasm of mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative stress in Fanconi anemia hematopoiesis and disease progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FANCE: the link between Fanconi anaemia complex assembly and activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA repair deficiency and acetaldehyde-induced chromosomal alterations in CHO cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokine production by bone marrow mononuclear cells in inherited bone marrow failure syndromes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biallelic inactivation of BRCA2 in Fanconi anemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of RAD51-dependent DNA interstrand cross-link repair.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A 20-year perspective on the International Fanconi Anemia Registry (IFAR).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Individualized risks of first adverse events in patients with Fanconi anemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Continuous in vivo infusion of interferon-gamma (IFN-gamma) preferentially reduces myeloid progenitor numbers and enhances engraftment of syngeneic wild-type cells in Fancc-/- mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
FANCL ubiquitinates β-catenin and enhances its nuclear function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overcoming reprogramming resistance of Fanconi anemia cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fetal origins of hematopoietic failure in a murine model of Fanconi anemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Learning from a paradox: recent insights into Fanconi anaemia through studying mouse models
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF-alpha regulates the effects of irradiation in the mouse bone marrow microenvironment.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1182%2FBLOOD-2013-09-427740
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1182/BLOOD-2013-09-427740
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1794061
OpenCitations bibliographic resource ID
1794061
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1794061
PubMed publication ID
24200684
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1794061
ResearchGate publication ID
258347483
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