(Q36083918)

English

Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

12 August 2017

Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells (English)

1 reference

Europe PubMed Central

12 August 2017

0 references

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Marina Cavazzana

13

object named as

Marina Cavazzana-Calvo

0 references

Régis Peffault de Latour

11

object named as

Régis Peffault de Latour

1 reference

Europe PubMed Central

12 August 2017

Qing-Shuo Zhang

object named as

Qing-Shuo Zhang

9

0 references

object named as

Marc Delord

4

0 references

Éliane Gluckman

object named as

Eliane Gluckman

12

0 references

object named as

Markus Grompe

16

0 references

17

object named as

Gérard Socié

1 reference

Europe PubMed Central

12 August 2017

Jérome Larghéro

15

object named as

Jérôme Larghero

1 reference

Europe PubMed Central

12 August 2017

Raphael Ceccaldi

1

object named as

Raphael Ceccaldi

1 reference

Europe PubMed Central

12 August 2017

Thierry Leblanc

14

object named as

Thierry Leblanc

1 reference

Europe PubMed Central

12 August 2017

18

object named as

Alan D D'Andrea

1 reference

Europe PubMed Central

12 August 2017

8

object named as

Nadia Vasquez

1 reference

Europe PubMed Central

12 August 2017

author name string

Kalindi Parmar

2

1 reference

Europe PubMed Central

12 August 2017

Enguerran Mouly

3

1 reference

Europe PubMed Central

12 August 2017

Jung Min Kim

5

1 reference

Europe PubMed Central

12 August 2017

Marie Regairaz

6

1 reference

Europe PubMed Central

12 August 2017

Marika Pla

7

1 reference

Europe PubMed Central

12 August 2017

Corinne Pondarre

10

1 reference

Europe PubMed Central

12 August 2017

Jean Soulier

19

1 reference

Europe PubMed Central

12 August 2017

language of work or name

0 references

publication date

7 June 2012

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

11

1 reference

Europe PubMed Central

12 August 2017

1

1 reference

Europe PubMed Central

12 August 2017

36-49

1 reference

Europe PubMed Central

12 August 2017

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Metabolism: alcohol, DNA and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

DNA interstrand crosslink repair and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

DNA-damage response in tissue-specific and cancer stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Spontaneous abrogation of the G₂DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Expanded roles of the Fanconi anemia pathway in preserving genomic stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Pathologies associated with the p53 response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Pathophysiology and management of inherited bone marrow failure syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Ribosomopathies: human disorders of ribosome dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Signaling to p53: ribosomal proteins find their way.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

How the fanconi anemia pathway guards the genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

The combined status of ATM and p53 link tumor development with therapeutic response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

p21 in cancer: intricate networks and multiple activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Mouse models of Fanconi anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Blinded by the Light: The Growing Complexity of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

p53 regulates hematopoietic stem cell quiescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

The genetic and molecular basis of Fanconi anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Differential p53 engagement in response to oxidative and oncogenic stresses in Fanconi anemia mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Stems cells and the pathways to aging and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

DNA repair pathways as targets for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

DNA repair is crucial for maintaining hematopoietic stem cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Inherited aplastic anaemias/bone marrow failure syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Hematopoietic stem cell transplantation in childhood inherited bone marrow failure syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Bone marrow failure as a risk factor for clonal evolution: prospects for leukemia prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

DNA repair is limiting for haematopoietic stem cells during ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Pathophysiologic mechanisms in acquired aplastic anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Hypoxia-reoxygenation induces premature senescence in FA bone marrow hematopoietic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

A system for stable expression of short interfering RNAs in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Functional heterogeneity of human CD34(+) cells isolated in subcompartments of the G0 /G1 phase of the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

The effect of the Fanconi anemia polypeptide, FAC, upon p53 induction and G2 checkpoint regulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Fanconi anemia genes act to suppress a cross-linker-inducible p53-independent apoptosis pathway in lymphoblastoid cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

G2 phase cell cycle disturbance as a manifestation of genetic cell damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

2 October 2017

Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

11 July 2018

A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

23 September 2018

Fanconi anemia proteins and endogenous stresses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

23 September 2018

Genotype-phenotype correlations in Fanconi anemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

23 September 2018

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

23 September 2018

Fanconi anaemia: new strategies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

23 September 2018

Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

23 September 2018

A 20-year perspective on the International Fanconi Anemia Registry (IFAR).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

23 September 2018

Impaired functionality and homing of Fancg-deficient hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

5 December 2018

Spontaneous functional correction of homozygous Fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392433

5 December 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of head and neck squamous cell cancer and death in patients with Fanconi anemia who did and did not receive transplants

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential DNA damage response in stem and progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22683204

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.STEM.2012.05.013

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

1 reference

Europe PubMed Central

12 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q36083918&oldid=2114081166"