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The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications
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scholarly article
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PubMed
title
The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications
(English)
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PubMed
main subject
pathophysiology
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based on heuristic
inferred from title
mitochondrion
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based on heuristic
inferred from title
author
Saverio Marchi
object named as
Saverio Marchi
series ordinal
1
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Paolo Pinton
object named as
Paolo Pinton
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2
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language of work or name
English
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stated in
PubMed
publication date
1 March 2014
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PubMed
published in
Journal of Physiology
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stated in
PubMed
volume
592
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PubMed
issue
5
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PubMed
page(s)
829-39
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PubMed
cites work
EMRE is an essential component of the mitochondrial calcium uniporter complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
NCLX is an essential component of mitochondrial Na+/Ca2+ exchange
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
A mitochondrial protein compendium elucidates complex I disease biology
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
Trypanosomes and the solution to a 50-year mitochondrial calcium mystery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
CaMKII determines mitochondrial stress responses in heart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
Innovation: Looking forward to seeing calcium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
MCU encodes the pore conducting mitochondrial calcium currents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
7 April 2017
MICU1 motifs define mitochondrial calcium uniporter binding and activity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Activity of the mitochondrial calcium uniporter varies greatly between tissues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Mitochondria as sensors and regulators of calcium signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
ATP synthesis and storage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Mitochondrial Ca(2+) and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Calcium signaling around Mitochondria Associated Membranes (MAMs).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
After half a century mitochondrial calcium in- and efflux machineries reveal themselves
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Calcium uptake mechanisms of mitochondria.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
LETM1, deleted in Wolf-Hirschhorn syndrome is required for normal mitochondrial morphology and cellular viability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Mitochondrial calcium transport
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Kinetics of calcium(2+) ion carrier in rat liver mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 September 2017
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
31 May 2018
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
31 May 2018
Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
31 May 2018
Evolutionary diversity of the mitochondrial calcium uniporter
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
31 May 2018
Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
31 May 2018
Isolation of a soluble Ca 2+ binding glycoprotein from ox liver mitochondria.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
31 May 2018
Electroneutral efflux of Ca2+ from liver mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
31 May 2018
Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 November 2018
Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 November 2018
Ca2+ homeostasis in the endoplasmic reticulum measured with a new low-Ca2+-affinity targeted aequorin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 November 2018
The mitochondrial calcium uniporter is a highly selective ion channel.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3948548
retrieved
28 November 2018
Inhibition of the mitochondrial calcium uniporter by antibodies against a 40-kDa glycoproteinT
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mitochondrial calcium uptake from physiological-type pulses of calcium. A description of the rapid uptake mode
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cell physiology: Cellular site of calcium regulation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Regulation of reverse uniport activity in mitochondria by extramitochondrial divalent cations. Dependence on a soluble intermembrane space component
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ca2+ metabolism in yeast cells and mitochondria
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Calcium transport sensitive to ruthenium red in cytochrome oxidase vesicles reconstituted with mitochondrial proteins
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Specific inhibition of mitochondrial Ca2+ transport by antibodies directed to the Ca2+-binding glycoprotein
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24366263
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1113/JPHYSIOL.2013.268235
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1310985
OpenCitations bibliographic resource ID
1310985
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1310985
PMCID
3948548
1 reference
stated in
PubMed
PubMed ID
24366263
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1310985
ResearchGate publication ID
259456133
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