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To BRAF or not to BRAF: is that even a question anymore?
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scholarly article
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Europe PubMed Central
title
To BRAF or not to BRAF: is that even a question anymore?
(English)
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stated in
PubMed
author name string
Craig Horbinski
series ordinal
1
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Crossref
language of work or name
English
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stated in
PubMed
publication date
January 2013
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PubMed
number of pages
6
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based on heuristic
inferred from page(s)
published in
Journal of Neuropathology & Experimental Neurology
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PubMed
volume
72
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PubMed
issue
1
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PubMed
page(s)
2-7
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PubMed
cites work
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
7 April 2017
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
7 April 2017
Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
7 April 2017
Raf kinases in cancer-roles and therapeutic opportunities
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
7 April 2017
Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
7 April 2017
Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Interplay among BRAF, p16, p53, and MIB1 in pediatric low-grade gliomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Targeted therapy for BRAFV600E malignant astrocytoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Mutant BRAF melanomas--dependence and resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Ras-induced senescence and its physiological relevance in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
MAPK pathway activation and the origins of pediatric low-grade astrocytomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Monoclonal antibody specific for IDH1 R132H mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
A practical view of 'druggability'.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Analysis of pilocytic astrocytoma by comparative genomic hybridization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
28 September 2017
Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
31 May 2018
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3530158
retrieved
31 May 2018
Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
BRAF alterations are frequent in cerebellar low-grade astrocytomas with diffuse growth pattern.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: a multi-institutional study.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Sensitive determination of BRAF copy number in clinical samples by pyrosequencing.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Mutation analysis of B-RAF gene in human gliomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Mutation analysis of the Ras pathway genes NRAS, HRAS, KRAS and BRAF in glioblastomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
KIAA1549-BRAF fusions and IDH mutations can coexist in diffuse gliomas of adults.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1097%2FNEN.0B013E318279F3DB
retrieved
21 January 2018
Gene expression profiling and subgroup identification of oligodendrogliomas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23242278
retrieved
12 December 2020
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Identifiers
DOI
10.1097/NEN.0B013E318279F3DB
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PMCID
3530158
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PubMed
PubMed ID
23242278
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PubMed
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