(Q34755317)

4 August 2017

title

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice (English)

1 reference

4 August 2017

main subject

pilocytic astrocytoma

1 reference

1 reference

13

Martin Bendszus

0 references

Till Milde

Till Milde

4

0 references

Marc Remke

Marc Remke

7

0 references

Peter Lichter

16

Peter Lichter

1 reference

4 August 2017

15

Stefan Pfister

1 reference

4 August 2017

2

Andrey Korshunov

1 reference

4 August 2017

10

David T W Jones

2 references

4 August 2017

ORCID Public Data File 2021

Eric C Holland

14

Eric C Holland

1 reference

4 August 2017

1

Jan Gronych

1 reference

4 August 2017

11

Olaf Witt

1 reference

4 August 2017

5

Manfred Jugold

1 reference

4 August 2017

Josephine Bageritz

3

1 reference

4 August 2017

Dolores Hambardzumyan

6

1 reference

4 August 2017

Christian Hartmann

8

1 reference

4 August 2017

Hendrik Witt

9

1 reference

4 August 2017

Sabine Heiland

12

1 reference

4 August 2017

language of work or name

English

0 references

publication date

14 March 2011

1 reference

Journal of Clinical Investigation

4 August 2017

published in

1 reference

4 August 2017

volume

121

1 reference

4 August 2017

issue

4

1 reference

4 August 2017

page(s)

1344-1348

1 reference

Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Modeling Adult Gliomas Using RCAS/t-va Technology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Constitutive activation of Raf-1 induces glioma formation in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Mouse models for BRAF-induced cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Cerebellar pilocytic astrocytoma: a treatment protocol based upon analysis of 73 cases and a review of the literature

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Activation of the ERK/MAPK pathway: a signature genetic defect in posterior fossa pilocytic astrocytomas.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069779

26 October 2018

Identifiers

DOI

10.1172/JCI44656

1 reference

4 August 2017

1 reference

4 August 2017

1 reference