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FOXO transcription factors: key regulators of cellular quality control
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scholarly article
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PubMed
review article
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Europe PubMed Central
title
FOXO transcription factors: key regulators of cellular quality control
(English)
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PubMed
main subject
quality control
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author name string
Ashley E. Webb
series ordinal
1
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Crossref
Anne Brunet
series ordinal
2
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Crossref
language of work or name
English
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stated in
PubMed
publication date
April 2014
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stated in
PubMed
published in
Trends in Biochemical Sciences
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PubMed
volume
39
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stated in
PubMed
page(s)
159-69
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stated in
PubMed
issue
4
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PubMed
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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
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Direct control of the Forkhead transcription factor AFX by protein kinase B
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28 September 2017
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28 September 2017
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans
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28 September 2017
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JNK regulates FoxO-dependent autophagy in neurons
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The role of ubiquitin-proteasome system in ageing.
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Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
FoxO transcription factors promote autophagy in cardiomyocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Fat metabolism links germline stem cells and longevity in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
FOXO transcription factors in ageing and cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Protein turnover via autophagy: implications for metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Progressive disruption of cellular protein folding in models of polyglutamine diseases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 September 2017
FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
FOXO4 is necessary for neural differentiation of human embryonic stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
Lipophagy: connecting autophagy and lipid metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
31 May 2018
RPN-6 determines C. elegans longevity under proteotoxic stress conditions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Autophagy is required to maintain muscle mass.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Age-dependent declines in proteasome activity in the heart
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Alteration of rat liver 20S proteasome activities by age and food restriction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4021867
retrieved
28 November 2018
Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24630600
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24630600
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24630600
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TIBS.2014.02.003
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
124907
Fatcat ID
release_kppbha56fvd7tls63aazqkaz6u
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/kppbha56fvd7tls63aazqkaz6u
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
124907
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
124907
PMCID
4021867
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
124907
PubMed ID
24630600
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
124907
ResearchGate publication ID
260840495
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