(Q35558459)

8 August 2017

1 reference

title

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. (English)

1 reference

ubiquitin-proteasome system

8 August 2017

0 references

1 reference

1

Aaron Ciechanover

1 reference

8 August 2017

2

Patrik Brundin

1 reference

PubMed ID

14556719

8 August 2017

language of work or name

English

0 references

publication date

1 October 2003

1 reference

8 August 2017

1 reference

8 August 2017

40

1 reference

8 August 2017

2

1 reference

8 August 2017

427-446

1 reference

The proteasome: structure, function, and role in the cell

8 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

?True? sporadic ALS associated with a novel SOD-1 mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Ubiquitin, cellular inclusions and their role in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Dentatorubral and pallidoluysian atrophy (DRPLA). Clinical and neuropathological findings in genetically confirmed North American and European pedigrees

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The septin CDCrel-1 binds syntaxin and inhibits exocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Degradation of alpha-synuclein by proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Copper and prion diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mice devoid of PrP are resistant to scrapie

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Oxidation versus aggregation - how do SOD1 mutants cause ALS?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasomal degradation of tau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The length of polyglutamine tract, its level of expression, the rate of degradation, and the transglutaminase activity influence the formation of intracellular aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Therapeutic effects of cystamine in a murine model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Part I: parkin-associated proteins and Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

When ubiquitin meets ubiquitin receptors: a signalling connection

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Characterization of chronic low-level proteasome inhibition on neural homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble form

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Activity and regulation of the centrosome-associated proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Identification of genes that modify ataxin-1-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Aggresome formation in liver cells in response to different toxic mechanisms: role of the ubiquitin-proteasome pathway and the frameshift mutant of ubiquitin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

alpha-Synuclein fibrils constitute the central core of oligodendroglial inclusion filaments in multiple system atrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Are ubiquitination pathways central to Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Are Huntington's and polyglutamine-based ataxias proteasome storage diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Could inhibition of the proteasome cause mad cow disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin is associated with actin filaments in neuronal and nonneural cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords--screening by molecular indexing and subsequent cDNA microarray analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

RING finger proteins: mediators of ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Aggresomes: a cellular response to misfolded proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Orchestrating the unfolded protein response in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Impaired proteasome function in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The proteasome in brain aging

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Neurodegenerative tauopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The ubiquitin pathway in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

A transgenic mouse model of the ubiquitin/proteasome system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Defective ubiquitination of cerebral proteins in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Relationship between beta-amyloid degradation and the 26S proteasome in neural cells

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Association between early-onset Parkinson's disease and mutations in the parkin gene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Transglutaminase potentiates ligand-dependent proteasome dysfunction induced by polyglutamine-expanded androgen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

1 reference

7 January 2021

Proteasomal function is impaired in substantia nigra in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteolytic stress: a unifying concept for the etiopathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Altered proteasomal function in sporadic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Gain in functions of mutant Cu,Zn-superoxide dismutases as a causative factor in familial amyotrophic lateral sclerosis: less reactive oxidant formation but high spontaneous aggregation and precipitation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mechanisms underlying ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Novel proteinaceous infectious particles cause scrapie

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Protein surveillance machinery in brains with spinocerebellar ataxia type 3: redistribution and differential recruitment of 26S proteasome subunits and chaperones to neuronal intranuclear inclusions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Homozygosity for CAG mutation in Huntington disease is associated with a more severe clinical course

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Transcriptional abnormalities in Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Toxic proteins in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Misfolded CuZnSOD and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Molecular misreading: a new type of transcript mutation expressed during aging.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Modification with SUMO. A role in transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

The 26S proteasome: a molecular machine designed for controlled proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Themes and variations on ubiquitylation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Complex relationship between Parkin mutations and Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Proteasomal Degradation and N-terminal Protease Resistance of the Codon 145 Mutant Prion Protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Glutamine repeats and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2803%2900606-8

7 January 2021

10.1016/S0896-6273(03)00606-8

Identifiers

DOI

1 reference

8 August 2017

1 reference

PubMed ID

14556719