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English
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.
scientific article published in January 2003
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
title
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
main subject
neurodegeneration
1 reference
based on heuristic
inferred from title
author
Ivelisse Sanchez
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
author name string
Christian Mahlke
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
Junying Yuan
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
language of work or name
English
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publication date
1 January 2003
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
published in
Nature
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
volume
421
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
page(s)
373-379
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
issue
6921
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
exact match
https://scigraph.springernature.com/pub.10.1038/nature01301
0 references
cites work
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
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inferred from DOI database lookup
Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
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Polar zippers: their role in human disease
1 reference
stated in
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reference URL
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retrieved
7 January 2021
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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
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Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A model for structure-dependent binding of Congo red to Alzheimer beta-amyloid fibrils.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-8 is required for cell death induced by expanded polyglutamine repeats.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
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inferred from DOI database lookup
Genetic suppression of polyglutamine toxicity in Drosophila
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impairment of the ubiquitin-proteasome system by protein aggregation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FNATURE01301
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/NATURE01301
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
Dimensions Publication ID
1017653700
0 references
PubMed ID
12540902
1 reference
stated in
Europe PubMed Central
PubMed ID
12540902
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json
retrieved
17 December 2019
ResearchGate publication ID
10939071
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