(Q44258606)

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Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

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Europe PubMed Central

PubMed publication ID

1 December 2017

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons (English)

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Europe PubMed Central

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1 December 2017

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Paul J. Lockhart

3

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1 December 2017

Matthew J. Farrer

9

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Europe PubMed Central

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1 December 2017

Leonard Petrucelli

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Leonard Petrucelli

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1 December 2017

John Anthony Hardy

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John Hardy

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1 December 2017

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Mark R Cookson

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1 December 2017

Casey A O'Farrell

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Casey O'Farrell

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1 December 2017

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Melisa Baptista

4

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1 December 2017

Kathryn Kehoe

5

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1 December 2017

Liselot Vink

6

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1 December 2017

Peter Choi

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1 December 2017

Benjamin Wolozin

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1 December 2002

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1 December 2017

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36

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1 December 2017

6

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Europe PubMed Central

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1 December 2017

1007-1019

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Europe PubMed Central

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1 December 2017

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

1 reference

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7 January 2021

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Impairment of the ubiquitin-proteasome system by protein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Degradation of alpha-synuclein by proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

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7 January 2021

based on heuristic

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

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7 January 2021

based on heuristic

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

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Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase.

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Expression of multiple proteins within single primary cortical neurons using a replication deficient HSV vector

1 reference

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7 January 2021

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Macromolecular crowding: an important but neglected aspect of the intracellular environment

1 reference

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Linkage exclusion in French families with probable Parkinson's disease

1 reference

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7 January 2021

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Lewy bodies and parkinsonism in families with parkin mutations

1 reference

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7 January 2021

based on heuristic

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A Drosophila model of Parkinson's disease

1 reference

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7 January 2021

based on heuristic

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Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

1 reference

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7 January 2021

based on heuristic

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Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae

1 reference

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7 January 2021

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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The ubiquitin system

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

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7 January 2021

based on heuristic

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Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The ubiquitin pathway in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteasomal function is impaired in substantia nigra in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Introduction of the glutamate receptor subunit 1 into motor neurons in vitro and in vivo using a recombinant herpes simplex virus

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of alpha-synuclein aggregation by intracellular nitrative insult.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Accelerated alpha-synuclein fibrillation in crowded milieu

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuropathology in mice expressing human alpha-synuclein

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2802%2901125-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0896-6273(02)01125-X

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 December 2017

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