(Q43819951)

English

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

scientific article published in December 2001

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scholarly article

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Europe PubMed Central

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4 December 2019

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death (English)

1 reference

Europe PubMed Central

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4 December 2019

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author name string

L Stefanis

1

1 reference

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4 December 2019

K E Larsen

2

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4 December 2019

H J Rideout

3

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4 December 2019

D Sulzer

4

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4 December 2019

L A Greene

5

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4 December 2019

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1 December 2001

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4 December 2019

Journal of Neuroscience

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4 December 2019

21

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4 December 2019

9549-9560

1 reference

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4 December 2019

24

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4 December 2019

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin pathway in Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasome inhibitors which induce neurite outgrowth from PC12h cells cause different subcellular accumulations of multi-ubiquitin chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural abnormalities associated with congenital megacolon in transgenic mice that overexpress the Hoxa-4 gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructure of Lewy bodies in the stellate ganglion

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of alpha-synuclein by proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An ultrastructural and immunohistochemical study of PC12 cells during apoptosis induced by serum deprivation with special reference to autophagy and lysosomal cathepsins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural aspects of autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurite outgrowth in PC12 cells. Distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-synuclein promotes mitochondrial deficit and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of quantal size by presynaptic mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein in Lewy bodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synuclein-1 is selectively up-regulated in response to nerve growth factor treatment in PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasomal function is impaired in substantia nigra in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-mediated proteolysis centers in HeLa cells: indication from studies of an inhibitor of the chymotrypsin-like activity of the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmed cell death (PCD). Apoptosis, autophagic PCD, or others?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine (3-hydroxytyramine) and brain function

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: a study using ubiquitin and PGP 9.5 immunocytochemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental cell death: morphological diversity and multiple mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53-dependent induction of apoptosis by proteasome inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure of the ubiquitin-proteasome system in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein overexpression promotes aggregation of mutant huntingtin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the cell death program by inhibition of proteasome function

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin, lysosomes, and neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin-proteasome pathway: on protein death and cell life

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synucleins in synaptic plasticity and neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11739566

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.21-24-09549.2001

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11739566%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11739566%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11739566%20AND%20SRC:MED&resulttype=core&format=json

4 December 2019

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