(Q34325371)

1 August 2017

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title

Failure of the ubiquitin-proteasome system in Parkinson's disease (English)

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ubiquitin-proteasome system

1 August 2017

main subject

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Isacson O

4

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ORCID Public Data File 2021

author name string

McNaught KS

1

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1 August 2017

Olanow CW

2

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1 August 2017

Halliwell B

3

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1 August 2017

Jenner P

5

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1 August 2017

language of work or name

English

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publication date

1 August 2001

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Nature Reviews Neuroscience

1 August 2017

published in

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1 August 2017

volume

2

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1 August 2017

issue

8

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1 August 2017

page(s)

589-594

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Alpha-synuclein and neurodegenerative diseases

1 August 2017

cites work

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Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease

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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

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Impaired clearance of oxidised proteins in neurodegenerative diseases

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Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation.

21 January 2018

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

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Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

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21 January 2018

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The proteasome, a novel protease regulated by multiple mechanisms

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A large kindred with autosomal dominant Parkinson's disease

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Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients

21 January 2018

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases

21 January 2018

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Protein nitration in Parkinson's disease

21 January 2018

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alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

21 January 2018

1 reference

Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

Dynamic association of proteasomal machinery with the centrosome

21 January 2018

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Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

Degradation of oxidized proteins by the 20S proteasome.

21 January 2018

1 reference

Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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A Drosophila model of Parkinson's disease

21 January 2018

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Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease

21 January 2018

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

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Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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The alpha-synuclein Ala53Thr mutation is not a common cause of familial Parkinson's disease: a study of 230 European cases. European Consortium on Genetic Susceptibility in Parkinson's Disease

21 January 2018

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Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

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Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

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Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex

21 January 2018

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Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

The ubiquitin pathway in Parkinson's disease

21 January 2018

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Clinical and neuropathological aspects of autosomal recessive juvenile parkinsonism

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

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Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

21 January 2018

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Ester bond-containing tea polyphenols potently inhibit proteasome activity in vitro and in vivo

21 January 2018

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Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production

21 January 2018

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Decreased levels of proteasome activity and proteasome expression in aging spinal cord

21 January 2018

1 reference

Caretaker or undertaker? The role of the proteasome in aging

21 January 2018

1 reference

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

21 January 2018

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cDNA cloning, expression, and functional characterization of PI31, a proline-rich inhibitor of the proteasome

21 January 2018

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Neuropathology of Parkinson's disease

21 January 2018

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7 January 2021

A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

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7 January 2021

Pathology and Biology of the Lewy Body

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7 January 2021

Clinical and pathological features of a parkinsonian syndrome in a family with an Ala53Thr ?-synuclein mutation

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7 January 2021

TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

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7 January 2021

Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.

1 reference

7 January 2021

The genetics of Parkinson's disease

1 reference

7 January 2021

Enhanced vulnerability to oxidative stress by alpha-synuclein mutations and C-terminal truncation

1 reference

7 January 2021

Structure/function in neuroprotection and apoptosis.

1 reference

7 January 2021

Degradation of alpha-synuclein by proteasome

1 reference

7 January 2021

Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients

1 reference

7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

7 January 2021

Understanding cell death in Parkinson's disease

1 reference

7 January 2021

A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease.

1 reference

7 January 2021

Identifiers

DOI

10.1038/35086067

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Dimensions Publication ID

1 August 2017

1001776700

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