(Q54066632)

24 May 2018

title

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. (English)

1 reference

24 May 2018

0 references

7

1 reference

24 May 2018

Huda Zoghbi

9

1 reference

24 May 2018

Aaron Ciechanover

6

object named as

A Ciechanover

1 reference

24 May 2018

C J Cummings

1

1 reference

24 May 2018

E Reinstein

2

1 reference

24 May 2018

Y Sun

3

1 reference

24 May 2018

B Antalffy

4

1 reference

24 May 2018

Y Jiang

5

1 reference

24 May 2018

A L Beaudet

8

1 reference

24 May 2018

language of work or name

English

0 references

publication date

1 December 1999

1 reference

24 May 2018

published in

Neuron

1 reference

24 May 2018

volume

24

1 reference

24 May 2018

issue

4

1 reference

24 May 2018

page(s)

879-892

1 reference

24 May 2018

Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Ubiquitin, cellular inclusions and their role in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

The proteasome: paradigm of a self-compartmentalizing protease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

The ubiquitin-proteasome pathway: on protein death and cell life

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Structure and functions of the 20S and 26S proteasomes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Functional analysis of the proteasome regulatory particle

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Hereditary dentatorubral-pallidoluysian atrophy: ubiquitinated filamentous inclusions in the cerebellar dentate nucleus neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Genetics of Angelman syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

The ubiquitin pathway in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

The cerebellar leucine-rich acidic nuclear protein interacts with ataxin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Apamin, a blocker of the calcium-activated potassium channel, induces neurodegeneration of Purkinje cells exclusively.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Protein fate in neurodegenerative proteinopathies: polyglutamine diseases join the (mis)fold

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Glutamine repeats and neurodegenerative diseases: molecular aspects

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

The ubiquitin-proteasome pathway and pathogenesis of human diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

A minimal glycine-alanine repeat prevents the interaction of ubiquitinated I kappaB alpha with the proteasome: a new mechanism for selective inhibition of proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

1 reference

7 January 2021

Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

Spinocerebellar ataxia: variable age of onset and linkage to human leukocyte antigen in a large kindred.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2981035-1

7 January 2021

10.1016/S0896-6273(00)81035-1

Identifiers

DOI

1 reference

24 May 2018

PubMed ID

10624951

1 reference

24 May 2018