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Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
main subject
amyotrophic lateral sclerosis
0 references
toxicity
0 references
author name string
J P Julien
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
language of work or name
English
0 references
publication date
1 February 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
published in
Cell
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
volume
104
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
page(s)
581-591
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
cites work
Glutamate slows axonal transport of neurofilaments in transfected neurons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
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inferred from DOI database lookup
Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
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inferred from DOI database lookup
Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Late onset of motor neurons in mice overexpressing wild-type peripherin
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
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7 January 2021
based on heuristic
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Formation of intermediate filament protein aggregates with disparate effects in two transgenic mouse models lacking the neurofilament light subunit
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ALS, SOD and peroxynitrite
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated "hydroxyl radical" generation in vivo in an animal model of amyotrophic lateral sclerosis.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superox
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linkage of the gene for an autosomal dominant form of juvenile amyotrophic lateral sclerosis to chromosome 9q34.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
From Charcot to SOD1: mechanisms of selective motor neuron death in ALS.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyotrophic lateral sclerosis immunoglobulins increase intracellular calcium in a motoneuron cell line
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extra axonal neurofilaments do not exacerbate disease caused by mutant Cu,Zn superoxide dismutase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal cord motor neurons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathogenesis of two axonopathies does not require axonal neurofilaments.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chronic mitochondrial inhibition induces selective motoneuron death in vitro: a new model for amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of neurofilament subunit NF-L and NF-H extends survival of a mouse model for amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered ionic conductances in axons of transgenic mouse expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extra neurofilament NF-L subunits rescue motor neuron disease caused by overexpression of the human NF-H gene in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The RNA of the glutamate transporter EAAT2 is variably spliced in amyotrophic lateral sclerosis and normal individuals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of apoptosis in mice with ALS
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitration of the low molecular weight neurofilament is equivalent in sporadic amyotrophic lateral sclerosis and control cervical spinal cord.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Toxicity of ALS-linked SOD1 mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0092-8674%2801%2900244-6
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0092-8674(01)00244-6
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
PubMed ID
11239414
1 reference
stated in
Europe PubMed Central
PubMed ID
11239414
retrieved
31 July 2017
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