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Emerging gene therapies for retinal degenerations
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PubMed
title
Emerging gene therapies for retinal degenerations
(English)
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stated in
PubMed
author name string
C. L. Cepko
series ordinal
1
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Crossref
language of work or name
English
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stated in
PubMed
publication date
9 May 2012
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stated in
PubMed
published in
Journal of Neuroscience
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stated in
PubMed
volume
32
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stated in
PubMed
issue
19
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PubMed
page(s)
6415-20
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PubMed
cites work
Longitudinal study of cone photoreceptors during retinal degeneration and in response to ciliary neurotrophic factor treatment
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Ruling out and ruling in neural codes
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Safety and efficacy of gene transfer for Leber's congenital amaurosis
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7 April 2017
Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration
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PubMed Central
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7 April 2017
Effect of gene therapy on visual function in Leber's congenital amaurosis
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CNTF and retina
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PubMed Central
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Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors
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7 April 2017
The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress
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The development and application of optogenetics
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PubMed Central
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Retinitis pigmentosa
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PubMed Central
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The microbial opsin family of optogenetic tools
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PubMed Central
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Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: a meta-analysis
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Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?
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PubMed Central
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28 September 2017
Encoding visual information in retinal ganglion cells with prosthetic stimulation
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PubMed Central
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28 September 2017
Pluripotent human stem cells for the treatment of retinal disease
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PubMed Central
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28 September 2017
Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration
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PubMed Central
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28 September 2017
Animal models of retinal disease
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PubMed Central
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28 September 2017
Retinal ganglion cell gene therapy and visual system repair
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PubMed Central
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28 September 2017
Intrinsically photosensitive retinal ganglion cells
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PubMed Central
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28 September 2017
Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.
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PubMed Central
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28 September 2017
Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
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28 September 2017
Evaluation of AAV-mediated expression of Chop2-GFP in the marmoset retina
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PubMed Central
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28 September 2017
Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling
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PubMed Central
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28 September 2017
Eye smarter than scientists believed: neural computations in circuits of the retina
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PubMed Central
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28 September 2017
Induced pluripotent stem cell therapies for retinal disease
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PubMed Central
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28 September 2017
Loss of responses to visual but not electrical stimulation in ganglion cells of rats with severe photoreceptor degeneration.
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PubMed Central
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28 September 2017
Animal models and different therapies for treatment of retinitis pigmentosa.
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PubMed Central
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28 September 2017
Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
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28 September 2017
Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
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28 September 2017
Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
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28 September 2017
Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
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28 September 2017
Improved retinal function in a mouse model of dominant retinitis pigmentosa following AAV-delivered gene therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Remodeling of cone photoreceptor cells after rod degeneration in rd mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Antioxidants reduce cone cell death in a model of retinitis pigmentosa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Application of encapsulated cell technology for retinal degenerative diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Identification and characterization of rod-derived cone viability factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Neural remodeling in retinal degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Oxidant signals and oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Partial characterization of retina-derived cone neuroprotection in two culture models of photoreceptor degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Cell death in retinitis pigmentosa: gap junctions and the 'bystander' effect
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
The fundamental plan of the retina
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Selective transplantation of rods delays cone loss in a retinitis pigmentosa model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 September 2017
Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
31 May 2018
Changes in adeno-associated virus-mediated gene delivery in retinal degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
31 May 2018
Ectopic expression of multiple microbial rhodopsins restores ON and OFF light responses in retinas with photoreceptor degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
31 May 2018
Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
31 May 2018
Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
31 May 2018
Differential effect of the rd mutation on rods and cones in the mouse retina
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
31 May 2018
Microbial rhodopsins in the spotlight
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Multi-site optical excitation using ChR2 and micro-LED array
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Adeno-associated virus-mediated rhodopsin replacement provides therapeutic benefit in mice with a targeted disruption of the rhodopsin gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Evaluation of the adeno-associated virus mediated long-term expression of channelrhodopsin-2 in the mouse retina
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Retinal ganglion cells survive and maintain normal dendritic morphology in a mouse model of inherited photoreceptor degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Retinal degenerations: planning for the future
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Protection of mouse photoreceptors by survival factors in retinal degenerations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392151
retrieved
28 November 2018
Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22573664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22573664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22573664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Retinal prosthetic strategy with the capacity to restore normal vision
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22573664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Preservation of the Inner Retina in Retinitis Pigmentosa
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22573664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Histopathology of the human retina in retinitis pigmentosa
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22573664
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1523/JNEUROSCI.0295-12.2012
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3428985
OpenCitations bibliographic resource ID
3428985
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3428985
PMC publication ID
3392151
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3428985
PubMed publication ID
22573664
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3428985
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