(Q26861535)

English

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes

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scholarly article

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20 November 2019

26 January 2021

4 February 2021

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PubMed publication ID

Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes (English)

1 reference

type 2 diabetes

2 references

20 November 2019

4 February 2021

insulin resistance

1 reference

20 August 2019

2 references

17 November 2019

26 January 2021

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J. Paananen

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Alessandro Doria

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A. Doria

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J. Dupuis

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T. Hansen

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Oluf Borbye Pedersen

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O. Pedersen

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Claudia Langenberg

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C. Langenberg

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M. Laakso

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Michael Boehnke

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M. Boehnke

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A. U. Jackson

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R. J. F. Loos

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E. Ingelsson

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Nicholas J. Wareham

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N. J. Wareham

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Jaakko Tuomilehto

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J. Tuomilehto

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Deborah A. Lawlor

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D. A. Lawlor

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Ramachandran S. Vasan

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R. S. Vasan

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Thomas Quertermous

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T. Quertermous

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Stefan Gustafsson

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S. Gustafsson

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J. B. Meigs

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Cornelia M. van Duijn

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C. van Duijn

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Hans-Ulrich Häring

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H. Haring

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Tanya M Teslovich

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T. M. Teslovich

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Eleuterio Ferrannini

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E. Ferrannini

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Francis Collins

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author name string

H. Yaghootkar

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R. A. Scott

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Z. Dastani

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M.-F. Hivert

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L. L. Warren

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A. Stancakova

7

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L.-P. Lyytikainen

9

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P. Henneman

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Y. Wu

11

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C. Y. Y. Cheung

12

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J. S. Pankow

13

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J. H. Zhao

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W. Xie

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R. N. Bergman

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F. el Bouazzaoui

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S. H. Dunn

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N. G. Forouhi

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C. Gillson

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A. T. Hattersley

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J. Hong

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M. Kahonen

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J. Kuusisto

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L. Kedenko

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F. Kronenberg

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T. L. Assimes

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K. Hao

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J. W. Knowles

39

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C. M. Lindgren

40

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J. J. Nolan

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U. Smith

45

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T. Lehtimaki

46

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C.-T. Liu

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M. I. McCarthy

49

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A. D. Morris

50

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K. W. van Dijk

55

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J. S. Viikari

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N. Zhu

57

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R. K. Semple

60

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C. N. A. Palmer

62

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M. Walker

63

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K. S. L. Lam

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B. Paulweber

65

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K. L. Mohlke

66

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O. T. Raitakari

68

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A. Bidulescu

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D. M. Waterworth

72

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J. B. Richards

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T. M. Frayling

76

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language of work or name

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publication date

October 2013

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1 October 2013

9 references

13 March 2019

14 March 2019

24 March 2019

20 June 2019

20 August 2019

17 November 2019

20 November 2019

26 January 2021

4 February 2021

10 references

13 March 2019

14 March 2019

24 March 2019

20 June 2019

20 August 2019

17 November 2019

20 November 2019

26 January 2021

4 February 2021

62

1 reference

10

1 reference

3589-98

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copyright license

Creative Commons Attribution-NonCommercial-NoDerivatives

9 references

13 March 2019

14 March 2019

24 March 2019

20 June 2019

20 August 2019

17 November 2019

20 November 2019

26 January 2021

4 February 2021

on focus list of Wikimedia project

0 references

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

21 March 2017

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

21 March 2017

Quantifying heterogeneity in a meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

21 March 2017

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

21 March 2017

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

21 March 2017

Disruption of adiponectin causes insulin resistance and neointimal formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

21 March 2017

METAL: fast and efficient meta-analysis of genomewide association scans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

7 April 2017

Adipocytokines: mediators linking adipose tissue, inflammation and immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

7 April 2017

Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

7 April 2017

Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Adiponectin in diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

The association studies of ADIPOQ with type 2 diabetes mellitus in Chinese populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Hypoadiponectinemia--cause or consequence of human "insulin resistance"?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Paradoxical elevation of high-molecular weight adiponectin in acquired extreme insulin resistance due to insulin receptor antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Glucose clamp technique: a method for quantifying insulin secretion and resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 September 2017

Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

31 May 2018

A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

31 May 2018

Genetic association of adiponectin with type 2 diabetes in Jordanian Arab population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: a meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Elevated levels of high-molecular-weight adiponectin in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Plasma Adiponectin as a Marker of Insulin Receptor Dysfunction: Clinical utility in severe insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Elevated plasma adiponectin and leptin levels in sisters with genetically defective insulin receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Elevated plasma adiponectin in humans with genetically defective insulin receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Adiponectin expression in adipose tissue is reduced in first-degree relatives of type 2 diabetic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3781444

28 November 2018

Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case-control study of Chinese Han population

1 reference

https://pubmed.ncbi.nlm.nih.gov/23835345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/23835345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23835345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp

1 reference

https://pubmed.ncbi.nlm.nih.gov/23835345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23835345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An association study of SNP + 45 T > G of the AdipoQ gene with type 2 diabetes in Yi and Han people in China

1 reference

https://pubmed.ncbi.nlm.nih.gov/23835345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/23835345

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB13-0128

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

release_6duvn34onvejdjbudslp7f5zpy

1 reference

https://api.fatcat.wiki/v0/release/6duvn34onvejdjbudslp7f5zpy

24 November 2022

based on heuristic

mapped directly with Wikidata item

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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