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Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice
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title
Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice
(English)
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PubMed
author name string
U. Hofer
series ordinal
1
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J. E. Henley
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2
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C. M. Exline
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3
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O. Mulhern
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4
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E. Lopez
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5
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P. M. Cannon
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6
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language of work or name
English
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PubMed
publication date
November 2013
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published in
Journal of Infectious Diseases
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PubMed
volume
208 Suppl 2
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PubMed
page(s)
S160-4
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cites work
Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice
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CCR5 deficiency increases risk of symptomatic West Nile virus infection
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21 March 2017
New generation humanized mice for virus research: comparative aspects and future prospects
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21 March 2017
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
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21 March 2017
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
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21 March 2017
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
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7 April 2017
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
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7 April 2017
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
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7 April 2017
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
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7 April 2017
Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient
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28 September 2017
Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
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PubMed Central
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28 September 2017
Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice
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28 September 2017
HIV-1 immunopathogenesis in humanized mouse models
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28 September 2017
Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.
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28 September 2017
The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment
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28 September 2017
An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice
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28 September 2017
Chemokine receptor 5 knockout strategies
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28 September 2017
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
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PubMed Central
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28 September 2017
Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody
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28 September 2017
A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807977
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28 September 2017
Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis
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PubMed Central
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28 September 2017
Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807977
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28 September 2017
Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807977
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28 September 2017
Cytokines and T-cell homeostasis
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28 September 2017
Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice
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PubMed Central
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28 September 2017
Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses
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PubMed Central
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28 September 2017
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
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reference URL
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28 September 2017
A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807977
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28 September 2017
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807977
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28 September 2017
NOD/SCID repopulating cells contribute only to short-term repopulation in the baboon
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3807977
retrieved
28 November 2018
Distinct hematopoietic stem/progenitor cell populations are responsible for repopulating NOD/SCID mice compared with nonhuman primates
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24151324
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
In vivo engraftment potential of clinical hematopoietic grafts
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24151324
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24151324
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/INFDIS/JIT382
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Fatcat ID
release_pz4tsjfkw5fypmvlvkb6in6u5i
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PMC publication ID
3807977
1 reference
stated in
PubMed
PubMed publication ID
24151324
1 reference
stated in
PubMed
ResearchGate publication ID
269842281
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