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Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity
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title
Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity
(English)
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author
Gerd Meyer zu Hörste
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2
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Gerd Meyer zu Horste
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Vijay Kuchroo
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3
object named as
Vijay K. Kuchroo
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author name string
Patrick R. Burkett
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1
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language of work or name
English
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publication date
June 2015
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published in
Journal of Clinical Investigation
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PubMed
volume
125
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PubMed
issue
6
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PubMed
page(s)
2211-9
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PubMed
cites work
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Fate mapping of IL-17-producing T cells in inflammatory responses
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Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling
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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
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Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
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21 March 2017
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
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The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
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21 March 2017
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
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Induction of intestinal Th17 cells by segmented filamentous bacteria
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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
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Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
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Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis
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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
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Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
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A validated regulatory network for Th17 cell specification
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Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
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Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
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The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
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Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
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Phenotypic and functional features of human Th17 cells
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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
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Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota.
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Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease
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Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis
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Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes
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Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
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28 September 2017
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation
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28 September 2017
The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.
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28 September 2017
A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis
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Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization
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28 September 2017
High fat diet accelerates pathogenesis of murine Crohn's disease-like ileitis independently of obesity
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Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora.
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28 September 2017
Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease
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Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease
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28 September 2017
Pathways in microbe-induced obesity
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Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
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Cutting edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet
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Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells
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28 September 2017
Dynamic regulatory network controlling TH17 cell differentiation
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28 September 2017
Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine
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28 September 2017
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis
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28 September 2017
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28 September 2017
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28 September 2017
IL-23: one cytokine in control of autoimmunity
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28 September 2017
Lymphotoxin regulates commensal responses to enable diet-induced obesity
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28 September 2017
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28 September 2017
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
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28 September 2017
Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice.
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28 September 2017
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.
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28 September 2017
n-3 fatty acids in cardiovascular disease
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28 September 2017
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.
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28 September 2017
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
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28 September 2017
Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
The changing demographic pattern of multiple sclerosis epidemiology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
A polymorphism within IL21R confers risk for systemic lupus erythematosus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
T-bet is essential for encephalitogenicity of both Th1 and Th17 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
A protective function for interleukin 17A in T cell-mediated intestinal inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Interleukin-21 is required for the development of type 1 diabetes in NOD mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
IL-21 limits peripheral lymphocyte numbers through T cell homeostatic mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Accelerated atherosclerosis in autoimmune rheumatic diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Intestinal, segmented, filamentous bacteria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 September 2017
Interaction between dietary sodium and smoking increases the risk for rheumatoid arthritis: results from a nested case-control study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
31 May 2018
Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
31 May 2018
Ustekinumab induction and maintenance therapy in refractory Crohn's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
31 May 2018
Interleukin-23 drives intestinal inflammation through direct activity on T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
31 May 2018
Novel association of the interleukin 2-interleukin 21 region with inflammatory bowel disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
31 May 2018
Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-gamma receptor-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
31 May 2018
Sodium intake is associated with increased disease activity in multiple sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Secukinumab in plaque psoriasis--results of two phase 3 trials
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
RGMA and IL21R show association with experimental inflammation and multiple sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
ATP drives lamina propria T(H)17 cell differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497747
retrieved
28 November 2018
Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25961452
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The association of interleukin-21 polymorphisms with interleukin-21 serum levels and risk of systemic lupus erythematosus
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25961452
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25961452
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25961452
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cutting Edge: IL-21 Is Not Essential for Th17 Differentiation or Experimental Autoimmune Encephalomyelitis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25961452
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25961452
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25961452
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1172/JCI78085
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
519104
Fatcat ID
release_lc6flxzz35hozkbd7uow3w72n4
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/lc6flxzz35hozkbd7uow3w72n4
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
519104
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
519104
PMC publication ID
4497747
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
519104
PubMed publication ID
25961452
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
519104
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