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Mechanisms of gene regulation by fatty acids
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PubMed
title
Mechanisms of gene regulation by fatty acids
(English)
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stated in
PubMed
main subject
fatty acid
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author
Sander Kersten
object named as
S. Kersten
series ordinal
2
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author name string
A. Georgiadi
series ordinal
1
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Crossref
language of work or name
English
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stated in
PubMed
publication date
1 March 2012
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stated in
PubMed
published in
Advances in Nutrition
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stated in
PubMed
volume
3
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stated in
PubMed
issue
2
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stated in
PubMed
page(s)
127-34
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stated in
PubMed
cites work
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
1 reference
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PubMed Central
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21 March 2017
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver
1 reference
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PubMed Central
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21 March 2017
Identification of an endogenous ligand bound to a native orphan nuclear receptor
1 reference
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PubMed Central
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21 March 2017
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
1 reference
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PubMed Central
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21 March 2017
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
1 reference
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PubMed Central
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21 March 2017
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
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PubMed Central
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21 March 2017
Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids
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PubMed Central
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21 March 2017
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
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PubMed Central
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21 March 2017
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
1 reference
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PubMed Central
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21 March 2017
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
1 reference
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PubMed Central
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21 March 2017
Structural basis for the activation of PPARgamma by oxidized fatty acids
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PubMed Central
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21 March 2017
Molecular recognition of nitrated fatty acids by PPARγ
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PubMed Central
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21 March 2017
Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
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21 March 2017
The nuclear receptor superfamily: the second decade
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21 March 2017
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.
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PubMed Central
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21 March 2017
2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans
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PubMed Central
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21 March 2017
Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
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PubMed Central
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21 March 2017
The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing
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PubMed Central
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21 March 2017
Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84
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PubMed Central
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21 March 2017
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
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21 March 2017
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
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PubMed Central
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21 March 2017
Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription
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21 March 2017
Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha
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PubMed Central
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21 March 2017
Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers
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PubMed Central
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21 March 2017
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
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21 March 2017
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
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21 March 2017
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
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21 March 2017
Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist
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21 March 2017
Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways
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21 March 2017
8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes
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21 March 2017
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta
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21 March 2017
TLR4 links innate immunity and fatty acid-induced insulin resistance
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7 April 2017
Nuclear receptors and lipid physiology: opening the X-files
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7 April 2017
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation
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15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
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7 April 2017
Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fed n-3 polyunsaturated fatty acids
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28 September 2017
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
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28 September 2017
VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses
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28 September 2017
Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis
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28 September 2017
Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis
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28 September 2017
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
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28 September 2017
Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids
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28 September 2017
Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.
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28 September 2017
Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease
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28 September 2017
Lipid receptors and islet function: therapeutic implications?
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28 September 2017
Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver
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28 September 2017
Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review.
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28 September 2017
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner
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28 September 2017
Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid x receptor in human choriocarcinoma BeWo cells
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28 September 2017
Lipoprotein lipase: from gene to obesity
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28 September 2017
Distribution and regulation of protein expression of the free fatty acid receptor GPR120.
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28 September 2017
Cellular and molecular effects of n-3 polyunsaturated fatty acids on adipose tissue biology and metabolism
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28 September 2017
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
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28 September 2017
Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics.
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28 September 2017
Free fatty acids induce cholecystokinin secretion through GPR120.
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28 September 2017
Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3.
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28 September 2017
Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
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28 September 2017
High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion.
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28 September 2017
14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha
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PubMed Central
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28 September 2017
Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase
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28 September 2017
Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids
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28 September 2017
PPARdelta is a very low-density lipoprotein sensor in macrophages
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28 September 2017
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
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PubMed Central
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28 September 2017
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
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PubMed Central
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28 September 2017
Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.
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PubMed Central
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28 September 2017
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.
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PubMed Central
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28 September 2017
Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
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28 September 2017
Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
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28 September 2017
Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells
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PubMed Central
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28 September 2017
Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor alpha.
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PubMed Central
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28 September 2017
Roles of PPARs in health and disease.
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28 September 2017
Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
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28 September 2017
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha
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28 September 2017
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
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28 September 2017
Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
31 May 2018
Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
31 May 2018
Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
31 May 2018
Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
31 May 2018
Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
31 May 2018
Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Peroxisome proliferator-activated receptor alpha target genes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Analysis of ligand-dependent recruitment of coactivator peptides to RXRbeta in a time-resolved fluorescence resonance energy transfer assay
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Peroxisome proliferator-activated receptor alpha interacts with high affinity and is conformationally responsive to endogenous ligands
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Contribution of fatty acids released from lipolysis of plasma triglycerides to total plasma fatty acid flux and tissue-specific fatty acid uptake.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3648713
retrieved
28 November 2018
Saturated fatty acids do not directly stimulate Toll-like receptor signaling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22516720
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22516720
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22516720
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ligand selectivity of the peroxisome proliferator-activated receptor alpha
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22516720
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22516720
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22516720
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3945/AN.111.001602
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1415653
OpenCitations bibliographic resource ID
1415653
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1415653
PMC publication ID
3648713
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1415653
PubMed publication ID
22516720
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1415653
ResearchGate publication ID
224769188
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