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Epigenetic regulation of fetal globin gene expression in adult erythroid cells
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scholarly article
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PubMed
title
Epigenetic regulation of fetal globin gene expression in adult erythroid cells
(English)
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stated in
PubMed
main subject
red blood cell
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inferred from title
author name string
Gordon D. Ginder
series ordinal
1
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Crossref
language of work or name
English
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stated in
PubMed
publication date
January 2015
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stated in
PubMed
published in
Translational Research
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stated in
PubMed
volume
165
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stated in
PubMed
page(s)
115-25
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stated in
PubMed
issue
1
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PubMed
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MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13
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Mi2β is required for γ-globin gene silencing: temporal assembly of a GATA-1-FOG-1-Mi2 repressor complex in β-YAC transgenic mice
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Developmental and species-divergent globin switching are driven by BCL11A
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Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic mice
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LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo
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MicroRNA-486-3p regulates γ-globin expression in human erythroid cells by directly modulating BCL11A.
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28 September 2017
Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.
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28 September 2017
A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia
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28 September 2017
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.
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28 September 2017
Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction
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28 September 2017
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28 September 2017
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28 September 2017
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes
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28 September 2017
Breaking the histone code with quantitative mass spectrometry.
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28 September 2017
A functional element necessary for fetal hemoglobin silencing
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PubMed Central
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28 September 2017
A pilot study of subcutaneous decitabine in β-thalassemia intermedia
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28 September 2017
Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells
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28 September 2017
Pharmacologic induction of fetal hemoglobin production
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28 September 2017
siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)-dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures
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28 September 2017
Fetal globin expression is regulated by Friend of Prmt1.
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28 September 2017
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease
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28 September 2017
Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression
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28 September 2017
Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.
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28 September 2017
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.
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PubMed Central
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28 September 2017
Advances in the understanding of haemoglobin switching
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28 September 2017
H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation
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28 September 2017
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
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28 September 2017
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
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PubMed Central
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28 September 2017
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
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PubMed Central
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28 September 2017
Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site.
1 reference
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PubMed Central
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28 September 2017
Epigenetic control of complex loci during erythropoiesis
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PubMed Central
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28 September 2017
Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin
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28 September 2017
Role of epigenetic modifications in normal globin gene regulation and butyrate-mediated induction of fetal hemoglobin
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28 September 2017
Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults
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PubMed Central
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28 September 2017
Embryonic and fetal beta-globin gene repression by the orphan nuclear receptors, TR2 and TR4.
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28 September 2017
Fine tuning of globin gene expression by DNA methylation
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28 September 2017
MBD2 is a critical component of a methyl cytosine-binding protein complex isolated from primary erythroid cells
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28 September 2017
Prospects for developing a molecular cure for thalassemia
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28 September 2017
Regulation of human fetal hemoglobin: new players, new complexities
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28 September 2017
DNA methylation and histone modifications: teaming up to silence genes
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28 September 2017
The molecular mechanism of fetal hemoglobin reactivation
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28 September 2017
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation
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28 September 2017
The many faces of histone lysine methylation
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28 September 2017
Structure and function of histone acetyltransferases
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28 September 2017
Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
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28 September 2017
Effects of DNA methylation on DNA-binding proteins and gene expression.
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28 September 2017
Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes
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PubMed Central
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28 September 2017
DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues
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PubMed Central
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28 September 2017
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia
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PubMed Central
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28 September 2017
Activation of a chicken embryonic globin gene in adult erythroid cells by 5-azacytidine and sodium butyrate
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28 September 2017
Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex
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PubMed Central
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28 September 2017
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons
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PubMed Central
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28 September 2017
Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 September 2017
X inactivation, differentiation, and DNA methylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 September 2017
Butyrate suppression of histone deacetylation leads to accumulation of multiacetylated forms of histones H3 and H4 and increased DNase I sensitivity of the associated DNA sequences
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 September 2017
Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 September 2017
Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
31 May 2018
MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
31 May 2018
The role of p22 NF-E4 in human globin gene switching
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
31 May 2018
The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
31 May 2018
The role of EKLF in human beta-globin gene competition.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
31 May 2018
Arabinosylcytosine Induces Fetal Hemoglobin in Baboons by Perturbing Erythroid Cell Differentiation Kinetics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
31 May 2018
Specific DNA methylation sites in the vicinity of the chicken beta-globin genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
31 May 2018
KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
Differentiation of human erythroid cells in culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
The SRA methyl-cytosine-binding domain links DNA and histone methylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
cMYB is involved in the regulation of fetal hemoglobin production in adults.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin disorders
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4227965
retrieved
28 November 2018
Chemistry. How are alkynes scrambled?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.05.002
retrieved
7 January 2021
Two-phase liquid culture system models normal human adult erythropoiesis at the molecular level
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.05.002
retrieved
7 January 2021
Differential binding of erythroid Krupple-like factor to embryonic/fetal globin gene promoters during development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.05.002
retrieved
7 January 2021
5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.05.002
retrieved
7 January 2021
Brief report: treatment with azacitidine of patients with end-stage beta-thalassemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.05.002
retrieved
7 January 2021
Augmentation of Fetal-Hemoglobin Production in Anemic Monkeys by Hydroxyurea
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.05.002
retrieved
7 January 2021
A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.05.002
retrieved
7 January 2021
DNA modification mechanisms and gene activity during development
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24880147
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Perturbations in the erythroid marrow progenitor cell pools may play a role in the augmentation of HbF by 5-azacytidine
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24880147
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TRSL.2014.05.002
0 references
PMCID
4227965
1 reference
stated in
PubMed
PubMed ID
24880147
1 reference
stated in
PubMed
ResearchGate publication ID
262383949
0 references
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