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Advances in the discovery of N-acylethanolamine acid amidase inhibitors
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title
Advances in the discovery of N-acylethanolamine acid amidase inhibitors
(English)
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PubMed
author
Daniele Piomelli
series ordinal
3
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author name string
Tiziano Bandiera
series ordinal
1
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Crossref
Stefano Ponzano
series ordinal
2
1 reference
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Crossref
language of work or name
English
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PubMed
publication date
August 2014
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PubMed
published in
Pharmacological Research
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PubMed
volume
86
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PubMed
page(s)
11-7
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PubMed
cites work
Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism
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PubMed Central
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Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha
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PubMed Central
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21 March 2017
A fatty gut feeling
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PubMed Central
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21 March 2017
Molecular characterization of a phospholipase D generating anandamide and its congeners
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PubMed Central
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21 March 2017
Human acid ceramidase: processing, glycosylation, and lysosomal targeting
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PubMed Central
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21 March 2017
Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice
1 reference
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PubMed Central
reference URL
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21 March 2017
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
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PubMed Central
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21 March 2017
Purification, characterization, and biosynthesis of human acid ceramidase
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PubMed Central
reference URL
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21 March 2017
Biochemical and mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase inhibition
1 reference
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PubMed Central
reference URL
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21 March 2017
Design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase (NAAA) inhibitor as anti-inflammatory compounds
1 reference
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PubMed Central
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21 March 2017
A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations
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PubMed Central
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21 March 2017
The molecular logic of endocannabinoid signalling
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PubMed Central
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7 April 2017
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
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PubMed Central
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7 April 2017
β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine
1 reference
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PubMed Central
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28 September 2017
Metabolism of endocannabinoids and related N-acylethanolamines: canonical and alternative pathways
1 reference
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PubMed Central
reference URL
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28 September 2017
Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Peroxisome proliferator-activated receptor α mediates acute effects of palmitoylethanolamide on sensory neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 September 2017
N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 September 2017
N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.
1 reference
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PubMed Central
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28 September 2017
Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis
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PubMed Central
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28 September 2017
The N-acylethanolamine-hydrolyzing acid amidase (NAAA).
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PubMed Central
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28 September 2017
Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha
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PubMed Central
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28 September 2017
The search for the palmitoylethanolamide receptor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Conjugated bile acid hydrolase is a tetrameric N-terminal thiol hydrolase with specific recognition of its cholyl but not of its tauryl product.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolysing N-acylethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
An anorexic lipid mediator regulated by feeding.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Beta-lactones as a new class of cysteine proteinase inhibitors: inhibition of hepatitis A virus 3C proteinase by N-Cbz-serine beta-lactone.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Control of pain initiation by endogenous cannabinoids.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
Biosynthesis, uptake, and degradation of anandamide and palmitoylethanolamide in leukocytes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
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28 September 2017
N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation
1 reference
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PubMed Central
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28 September 2017
Structural comparison of Ntn-hydrolases.
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PubMed Central
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31 May 2018
Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Esters, Retroesters, and a Retroamide of Palmitic Acid: Pool for the First Selective Inhibitors of N-Palmitoylethanolamine- Selective Acid Amidase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4117721
retrieved
28 November 2018
Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24798679
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24798679
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24798679
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24798679
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24798679
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Acute Intracerebroventricular Administration of Palmitoylethanolamide, an Endogenous Peroxisome Proliferator-Activated Receptor- Agonist, Modulates Carrageenan-Induced Paw Edema in Mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24798679
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Endogenous Phospholipid Metabolite Containing Topical Product Inhibits Ultraviolet Light-Induced Inflammation and DNA Damage in Human Skin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24798679
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.PHRS.2014.04.011
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2378894
OpenCitations bibliographic resource ID
2378894
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2378894
PMC publication ID
4117721
1 reference
stated in
PubMed
PubMed publication ID
24798679
1 reference
stated in
PubMed
ResearchGate publication ID
262075918
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