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Chemoenzymatic synthesis of heparan sulfate and heparin
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title
Chemoenzymatic synthesis of heparan sulfate and heparin
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main subject
heparin
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author
Robert J. Linhardt
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2
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Robert J. Linhardt
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Jian Liu
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object named as
Jian Liu
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language of work or name
English
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publication date
December 2014
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published in
Natural Product Reports
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volume
31
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PubMed
issue
12
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PubMed
page(s)
1676-85
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PubMed
cites work
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Engineering of routes to heparin and related polysaccharides
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The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate
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Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells
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21 March 2017
Dissecting the substrate recognition of 3-O-sulfotransferase for the biosynthesis of anticoagulant heparin
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21 March 2017
Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1
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21 March 2017
Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase
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21 March 2017
Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate
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PubMed Central
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21 March 2017
Heparan sulphate proteoglycans fine-tune mammalian physiology
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7 April 2017
Order out of chaos: assembly of ligand binding sites in heparan sulfate
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PubMed Central
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7 April 2017
Synthetic oligosaccharides as active pharmaceutical ingredients: lessons learned from the full synthesis of one heparin derivative on a large scale
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PubMed Central
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28 September 2017
Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase
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28 September 2017
De novo synthesis of a narrow size distribution low-molecular-weight heparin
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28 September 2017
Fibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing
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PubMed Central
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28 September 2017
Homogeneous low-molecular-weight heparins with reversible anticoagulant activity
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PubMed Central
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28 September 2017
Towards the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl group with ceric ammonium salts
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PubMed Central
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28 September 2017
Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies
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28 September 2017
Synthesis of a targeted library of heparan sulfate hexa- to dodecasaccharides as inhibitors of β-secretase: potential therapeutics for Alzheimer's disease
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28 September 2017
Deciphering mode of action of heparanase using structurally defined oligosaccharides
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28 September 2017
Chemoenzymatic synthesis of heparin oligosaccharides with both anti-factor Xa and anti-factor IIa activities
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PubMed Central
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28 September 2017
Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis
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PubMed Central
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28 September 2017
Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans
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PubMed Central
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28 September 2017
Chemoenzymatic synthesis of homogeneous ultralow molecular weight heparins
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28 September 2017
Renal profiles of anticoagulants
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28 September 2017
Enzymatic placement of 6-O-sulfo groups in heparan sulfate
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PubMed Central
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28 September 2017
The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate
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PubMed Central
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28 September 2017
Chemoenzymatic Design of Heparan Sulfate Oligosaccharides*
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PubMed Central
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28 September 2017
Preactivation-based, one-pot combinatorial synthesis of heparin-like hexasaccharides for the analysis of heparin-protein interactions.
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28 September 2017
Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies.
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28 September 2017
Lessons learned from the contamination of heparin
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PubMed Central
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28 September 2017
Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin
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PubMed Central
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28 September 2017
Beyond unfractionated heparin and warfarin: current and future advances
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28 September 2017
Chemoenzymatic synthesis with distinct Pasteurella heparosan synthases: monodisperse polymers and unnatural structures.
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28 September 2017
Beyond heparin and warfarin: the new generation of anticoagulants
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PubMed Central
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28 September 2017
Determination of the substrate specificities of N-acetyl-d-glucosaminyltransferase
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28 September 2017
Clinical practice. Heparin-induced thrombocytopenia
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28 September 2017
Microarrays of synthetic heparin oligosaccharides.
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PubMed Central
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28 September 2017
Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2.
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PubMed Central
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28 September 2017
Enzymatic synthesis of antithrombin III–binding heparan sulfate pentasaccharide
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PubMed Central
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28 September 2017
The origin of the dispute over the discovery of heparin
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28 September 2017
Synthesis of heparin fragments: a methyl alpha-pentaoside with high affinity for antithrombin III.
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Synthetic heparin
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PubMed Central
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28 September 2017
Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems
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31 May 2018
Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host-cell interaction
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31 May 2018
Control of the heparosan N-deacetylation leads to an improved bioengineered heparin
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31 May 2018
Anomeric reactivity-based one-pot synthesis of heparin-like oligosaccharides
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31 May 2018
2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.
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31 May 2018
Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line.
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31 May 2018
Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the (1)C(4) and (2)S(O) conformations of a bioactive heparin-like hexasaccharide.
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21 January 2018
Biosynthesis of heparin/heparan sulfate. cDNA cloning and expression of D-glucuronyl C5-epimerase from bovine lung
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21 January 2018
Design of biologically active heparan sulfate and heparin using an enzyme-based approach
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21 January 2018
Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharides
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21 January 2018
Purification and characterization of heparan sulfate 2-sulfotransferase from cultured Chinese hamster ovary cells
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PubMed
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12 December 2020
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inferred from PubMed ID database lookup
UDP-N-trifluoroacetylglucosamine as an alternative substrate in N-acetylglucosaminyltransferase reactions
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25197032
retrieved
12 December 2020
based on heuristic
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Chemistry. Getting the farm out of pharma for heparin production
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25197032
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sugars slide into heparin activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25197032
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1039/C4NP00076E
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4557217
OpenCitations bibliographic resource ID
4557217
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4557217
PMC publication ID
4387879
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4557217
PubMed publication ID
25197032
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4557217
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