(Q27006981)

English

Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

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scholarly article

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Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression (English)

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protein ubiquitination

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based on heuristic

inferred from title

phosphorylation

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based on heuristic

inferred from title

Harald Stenmark

2

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author name string

Hilde Abrahamsen

1

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Harald W. Platta

3

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language of work or name

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publication date

4 June 2012

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586

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11

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1584-91

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The emerging mechanisms of isoform-specific PI3K signalling

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The regulation and function of Class III PI3Ks: novel roles for Vps34.

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Endocytosis and signaling

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Defective downregulation of receptor tyrosine kinases in cancer

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Cytokinesis and cancer

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Cytokinesis, ploidy and aneuploidy

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The Beclin 1 network regulates autophagy and apoptosis

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The Beclin 1 interactome

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Beclin 1 self-association is independent of autophagy induction by amino acid deprivation and rapamycin treatment.

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

An overview of Cdk1-controlled targets and processes

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Negative regulation of Vps34 by Cdk mediated phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Ubiquitin networks in cancer

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Modification of proteins by ubiquitin and ubiquitin-like proteins

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Molecular mechanisms of ubiquitin-dependent membrane traffic

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The spatial and temporal organization of ubiquitin networks

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Association between early-onset Parkinson's disease and mutations in the parkin gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Parkin mono-ubiquitinates Bcl-2 and regulates autophagy

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Ubiquitin-binding domains

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Defining the human deubiquitinating enzyme interaction landscape

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

K11-linked ubiquitin chains as novel regulators of cell division

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Global identification of modular cullin-RING ligase substrates

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Network organization of the human autophagy system

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Systematic and quantitative assessment of the ubiquitin-modified proteome

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

mTOR regulation of autophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

mTOR: from growth signal integration to cancer, diabetes and ageing

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Parkin interacts with Ambra1 to induce mitophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2012.04.046

21 January 2018

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10.1016/J.FEBSLET.2012.04.046

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release_jbdgru4dhzh25aeqfx4xsklgsq

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