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Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle
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scholarly article
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title
Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle
(English)
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author name string
S. R. Kimball
series ordinal
1
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language of work or name
English
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PubMed
publication date
January 2014
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PubMed
published in
American Journal of Clinical Nutrition
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PubMed
volume
99
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PubMed
issue
1
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PubMed
page(s)
237S-242S
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PubMed
cites work
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
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PubMed Central
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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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21 March 2017
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
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PubMed Central
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
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PubMed Central
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21 March 2017
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
1 reference
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PubMed Central
reference URL
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21 March 2017
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
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PubMed Central
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21 March 2017
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
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PubMed Central
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21 March 2017
Identification and characterization of a lysosomal transporter for small neutral amino acids
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PubMed Central
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21 March 2017
Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
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PubMed Central
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21 March 2017
Multicompartmental distribution of the tuberous sclerosis gene products, hamartin and tuberin
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PubMed Central
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21 March 2017
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
1 reference
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PubMed Central
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21 March 2017
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
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21 March 2017
Rheb binds and regulates the mTOR kinase
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PubMed Central
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21 March 2017
The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation
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21 March 2017
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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7 April 2017
Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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28 September 2017
Interactions between exercise and nutrition to prevent muscle waste during ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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28 September 2017
Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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28 September 2017
mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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28 September 2017
Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 September 2017
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 September 2017
Mechanisms involved in the coordinate regulation of mTORC1 by insulin and amino acids
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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28 September 2017
Skeletal muscle gene expression in response to resistance exercise: sex specific regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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28 September 2017
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 September 2017
Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 September 2017
Human muscle gene expression following resistance exercise and blood flow restriction.
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 September 2017
The Rheb family of GTP-binding proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
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28 September 2017
Bidirectional modulation of insulin action by amino acids
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 September 2017
Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
31 May 2018
Blunting of adaptive responses to resistance exercise training in women over 75y.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Involvement of PI3K/Akt/TOR pathway in stretch-induced hypertrophy of myotubes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Regulation of translation initiation by insulin and amino acids in skeletal muscle of neonatal pigs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Effects of intensity of acute-resistance exercise on rates of protein synthesis in moderately diabetic rats.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3862457
retrieved
28 November 2018
Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24284445
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24284445
retrieved
12 December 2020
based on heuristic
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Identifiers
DOI
10.3945/AJCN.113.068387
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PMCID
3862457
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PubMed
PubMed ID
24284445
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PubMed
ResearchGate publication ID
258957790
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