(Q54614762)

1 June 2018

title

Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. (English)

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1 June 2018

4

Karyn A Esser

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1 June 2018

author name string

Mitsunori Miyazaki

series ordinal

1

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1 June 2018

John J McCarthy

series ordinal

2

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1 June 2018

Mark J Fedele

series ordinal

3

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1 June 2018

language of work or name

English

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publication date

7 February 2011

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1 June 2018

number of pages

16

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inferred from page(s)

published in

Journal of Physiology

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1 June 2018

volume

589

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1 June 2018

issue

Pt 7

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1 June 2018

page(s)

1831-1846

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1 June 2018

A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy

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High-frequency electrically stimulated skeletal muscle contractions increase p70s6k phosphorylation independent of known IGF-I sensitive signaling pathways

2 November 2018

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Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

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2 November 2018

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Changes in muscle mass with mechanical load: possible cellular mechanisms

2 November 2018

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Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis

2 November 2018

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COX-2 inhibitor reduces skeletal muscle hypertrophy in mice.

2 November 2018

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REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch

2 November 2018

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Serum IGF-I-deficiency does not prevent compensatory skeletal muscle hypertrophy in resistance exercise

2 November 2018

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Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals

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The RSK family of kinases: emerging roles in cellular signalling

2 November 2018

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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

2 November 2018

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A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy.

2 November 2018

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Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

2 November 2018

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

2 November 2018

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RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

2 November 2018

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Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass

2 November 2018

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Involvement of the ERK1/2 MAPK pathway in insulin-induced S6K1 activation in avian cells

2 November 2018

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MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Skeletal muscle hypertrophy and atrophy signaling pathways

2 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators

2 November 2018

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

2 November 2018

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Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

2 November 2018

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Contribution of the calcineurin signaling pathway to overload-induced skeletal muscle fiber-type transition.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

2 November 2018

1 reference

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Tor signalling in bugs, brain and brawn

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

GSK-3beta negatively regulates skeletal myotube hypertrophy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Selected Contribution: IGF-I antibody prevents increases in protein synthesis in epitrochlearis muscles from refed, diabetic rats

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Time course of changes in markers of myogenesis in overloaded rat skeletal muscles

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Normal growth and development in the absence of hepatic insulin-like growth factor I

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Control of p70 s6 kinase by kinase activity of FRAP in vivo

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Work-induced growth of skeletal muscle in normal and hypophysectomized rats

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Growth hormone regulates the level of insulin-like growth factor-I mRNA in rat skeletal muscle

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Immunological localization of ribosomes in striated rat muscle. Evidence for myofibrillar association and ontological changes in the subsarcolemmal:myofibrillar distribution

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3099033

Intracellular signaling specificity in skeletal muscle in response to different modes of exercise

2 November 2018

1 reference

12 December 2020

Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

1 reference

12 December 2020

Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise

1 reference

12 December 2020

Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure

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12 December 2020

10.1113/JPHYSIOL.2011.205658

Identifiers

DOI

1 reference

1 June 2018

PMC publication ID

3099033

0 references

1 reference

1 June 2018