(Q27024533)

21 June 2017

title

Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. (English)

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21 June 2017

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Marco Bortolato

2

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21 June 2017

Segev Barak

5

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21 June 2017

Dorit Ron

6

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21 June 2017

Jing Liang

7

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21 June 2017

Daryl L Davies

1

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21 June 2017

Deborah A Finn

3

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21 June 2017

Marcia J Ramaker

4

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21 June 2017

Richard W Olsen

8

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21 June 2017

language of work or name

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4 June 2012

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Alcoholism: Clinical and Experimental Research

21 June 2017

published in

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21 June 2017

volume

37

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21 June 2017

issue

1

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21 June 2017

page(s)

8-15

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Genetical genomic determinants of alcohol consumption in rats and humans

21 June 2017

cites work

1 reference

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GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse

21 March 2017

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Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513

21 March 2017

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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

21 March 2017

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The GDNF family: signalling, biological functions and therapeutic value

21 March 2017

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Allosteric control of gating and kinetics at P2X(4) receptor channels

21 March 2017

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Neurosteroids: endogenous regulators of the GABA(A) receptor

21 March 2017

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Increased extracellular dopamine concentrations and FosB/DeltaFosB expression in striatal brain areas of heterozygous GDNF knockout mice

21 March 2017

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Ivermectin reduces alcohol intake and preference in mice.

21 March 2017

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Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption

28 September 2017

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Dihydromyricetin as a novel anti-alcohol intoxication medication.

28 September 2017

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28 September 2017

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Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors

28 September 2017

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Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking

28 September 2017

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Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution

28 September 2017

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Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol

28 September 2017

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Implication of the purinergic system in alcohol use disorders.

28 September 2017

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Nucleus accumbens-derived glial cell line-derived neurotrophic factor is a retrograde enhancer of dopaminergic tone in the mesocorticolimbic system

28 September 2017

1 reference

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Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats

28 September 2017

1 reference

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Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors

28 September 2017

1 reference

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Medication treatment of different types of alcoholism

28 September 2017

1 reference

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New ventures in the genotoxic and cytotoxic effects of macrocyclic lactones, abamectin and ivermectin

28 September 2017

1 reference

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Role of BDNF and GDNF in drug reward and relapse: a review

28 September 2017

1 reference

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A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

GDNF--a potential target to treat addiction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Ethanol intake patterns in female mice: influence of allopregnanolone and the inhibition of its synthesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Ivermectin: 25 years and still going strong

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Topiramate for treating alcohol dependence: a randomized controlled trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

GABAergic modulation of binge-like ethanol intake in C57BL/6J mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Drug insight: Cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Alcohol-sensitive GABA receptors and alcohol antagonists

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Ivermectin 20 years on: maturation of a wonder drug

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Ethanol differentially affects ATP-gated P2X(3) and P2X(4) receptor subtypes expressed in Xenopus oocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

An extract of the Chinese herbal root kudzu reduces alcohol drinking by heavy drinkers in a naturalistic setting

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

The mechanism by which ethanol inhibits rat P2X4 receptors is altered by mutation of histidine 241.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Efficacy and safety of naltrexone and acamprosate in the treatment of alcohol dependence: a systematic review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

GABA(A) receptor modulation of the rewarding and aversive effects of ethanol

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Pharmacologically targeting the P2rx4 gene on maintenance and reinstatement of alcohol self-administration in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Acamprosate and diazepam differentially modulate alcohol-induced behavioural and cortical alterations in rats following chronic inhalation of ethanol vapour

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Alcohol withdrawal in rats is associated with a marked fall in extraneuronal dopamine

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3443504

Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor

31 May 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Ethanol sensitivity in ATP-gated P2X receptors is subunit dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Enduring effects of chronic ethanol in the CNS: basis for alcoholism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

Long-term reduction in ventral tegmental area dopamine neuron population activity following repeated stimulant or ethanol treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1530-0277.2012.01846.X

10.1111/J.1530-0277.2012.01846.X

21 January 2018

Identifiers

DOI

1 reference

release_n6yb7bxo6veqdga42zd5oe6o5y

21 June 2017

Fatcat ID

0 references

1 reference

1 reference