(Q27024588)

title

Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity (English)

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

2

Betty Diamond

2 references

Crossref

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

1 reference

June 2015

1 reference

Journal of Clinical Investigation

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

125

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

2194-2202

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

10 June 2020

cites work

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21 March 2017

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21 March 2017

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28 September 2017

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28 September 2017

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Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice

28 September 2017

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Citrullination of autoantigens implicates NETosis in the induction of autoimmunity.

28 September 2017

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Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.

28 September 2017

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Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

28 September 2017

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28 September 2017

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Anti-DNA antibodies cross-react with C1q

28 September 2017

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Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

28 September 2017

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NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis

28 September 2017

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Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

28 September 2017

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C1q limits dendritic cell differentiation and activation by engaging LAIR-1

28 September 2017

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Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice

28 September 2017

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Anti-neutrophil cytoplasmic antibodies stimulate release of neutrophil microparticles

28 September 2017

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Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells

28 September 2017

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Basophils and the T helper 2 environment can promote the development of lupus nephritis

28 September 2017

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28 September 2017

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Cutting edge: cardiac myosin activates innate immune responses through TLRs

28 September 2017

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28 September 2017

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Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

28 September 2017

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Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

28 September 2017

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28 September 2017

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Complement deficiencies and systemic lupus erythematosus

28 September 2017

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B cell intrinsic TLR signals amplify but are not required for humoral immunity

28 September 2017

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BAFF and MyD88 signals promote a lupuslike disease independent of T cells

28 September 2017

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CpG DNA stimulates autoreactive immature B cells in the bone marrow

28 September 2017

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Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

28 September 2017

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Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis

28 September 2017

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TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.

28 September 2017

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

28 September 2017

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Clinical significance of IgA anticardiolipin and anti-beta2-GP1 antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome

28 September 2017

1 reference

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The evolution of human anti-double-stranded DNA autoantibodies

28 September 2017

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Impaired early B cell tolerance in patients with rheumatoid arthritis.

28 September 2017

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Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts worse disease activity and greater radiological progression

28 September 2017

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

28 September 2017

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Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy

28 September 2017

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Receptor editing in peripheral B cell tolerance

28 September 2017

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Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry

28 September 2017

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28 September 2017

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A systematic analysis of sequences of human antiphospholipid and anti-beta2-glycoprotein I antibodies: the importance of somatic mutations and certain sequence motifs

28 September 2017

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Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin

28 September 2017

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Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM.

28 September 2017

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B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.

28 September 2017

1 reference

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Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.

28 September 2017

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Experimental expression in mice and spontaneous expression in human SLE of polyomavirus T-antigen. A molecular basis for induction of antibodies to DNA and eukaryotic transcription factors

28 September 2017

1 reference

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Peptide inhibition of glomerular deposition of an anti-DNA antibody

28 September 2017

1 reference

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An in vitro assay for detection of glomerular binding IgG autoantibodies in patients with systemic lupus erythematosus

28 September 2017

1 reference

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Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease

28 September 2017

1 reference

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Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus

28 September 2017

1 reference

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Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis

28 September 2017

1 reference

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Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus

28 September 2017

1 reference

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Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus

28 September 2017

1 reference

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Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity

28 September 2017

1 reference

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Natural antibody to apoptotic cell membranes inhibits the proinflammatory properties of lupus autoantibody immune complexes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies

31 May 2018

1 reference

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Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells

28 November 2018

1 reference

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Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

28 November 2018

1 reference

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Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

28 November 2018

1 reference

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Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

The ACPA recognition profile and subgrouping of ACPA-positive RA patients

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

TLR ligation triggers somatic hypermutation in transitional B cells inducing the generation of IgM memory B cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.

28 November 2018

1 reference

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Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Interaction of histones with phospholipids--implications for the exposure of histones on apoptotic cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Isotype distribution of ANTI–CYCLIC citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Nucleosomes are exposed at the cell surface in apoptosis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

BAFF mediates survival of peripheral immature B lymphocytes

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4497746

Activation of autoreactive B cells by CpG dsDNA

28 November 2018

1 reference

12 December 2020

Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidney

1 reference

12 December 2020

[Absorption of L. E. factor by isolated cell nuclei]

1 reference

12 December 2020

Complement cascade in systemic lupus erythematosus: analyses of the three activation pathways.

1 reference

12 December 2020

Evidence that human immunoglobulin M rheumatoid factors can Be derived from the natural autoantibody pool and undergo an antigen driven immune response in which somatically mutated rheumatoid factors have lower affinities for immunoglobulin G Fc tha

1 reference

12 December 2020

Complement fixation with cell nuclei and DNA in lupus erythematosus

1 reference

12 December 2020

Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis

1 reference

12 December 2020

TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses

1 reference

12 December 2020

A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells

1 reference

12 December 2020

Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

1 reference

12 December 2020

Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens

1 reference

12 December 2020

Development of the anti-citrullinated protein antibody repertoire prior to the onset of rheumatoid arthritis

1 reference

12 December 2020

Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α-enolase and arthritis in DR4-IE-transgenic mice

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI78084

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25938780%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

2 references