(Q27025076)

English

The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

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scholarly article

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The unmet need in the elderly: how immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines (English)

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vaccine development

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influenza vaccine

1 reference

based on heuristic

inferred from title

object named as

Graham Pawelec

7

0 references

Helen Keipp Talbot

3

object named as

H. Keipp Talbot

1 reference

Janet E McElhaney

1

object named as

Janet E. McElhaney

1 reference

author name string

Xin Zhou

2

1 reference

Ernst Soethout

4

1 reference

R. Chris Bleackley

5

1 reference

David J. Granville

6

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language of work or name

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publication date

9 March 2012

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30

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12

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2060-7

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Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

1 reference

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21 March 2017

Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm

1 reference

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21 March 2017

Frailty in older adults: evidence for a phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

21 March 2017

Seroprevalence of cytomegalovirus infection in the United States, 1988-1994

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21 March 2017

Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care

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21 March 2017

A synthetic adjuvant to enhance and expand immune responses to influenza vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

21 March 2017

Influenza-associated hospitalizations in the United States

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7 April 2017

Mortality associated with influenza and respiratory syncytial virus in the United States

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7 April 2017

GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

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28 September 2017

Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm

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28 September 2017

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Relationship between functional ability in older people, immune system status, and intensity of response to CMV

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28 September 2017

Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age.

1 reference

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28 September 2017

Granzyme B as a novel factor involved in cardiovascular diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Inflammatory markers in population studies of aging

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28 September 2017

Age effects on B cells and humoral immunity in humans

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28 September 2017

Update: influenza activity - United States, 2009-10 season

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28 September 2017

Clinical and immunologic predictors of influenza illness among vaccinated older adults

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28 September 2017

Aging, frailty and age-related diseases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Cytomegalovirus infection and the risk of mortality and frailty in older women: a prospective observational cohort study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Update: influenza activity - United States, August 30, 2009-March 27, 2010, and composition of the 2010-11 influenza vaccine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Influenza-induced production of interferon-alpha is defective in geriatric individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Granzymes in age-related cardiovascular and pulmonary diseases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Challenges in evaluating influenza vaccine effectiveness and the mortality benefits controversy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Influenza vaccination and mortality benefits: new insights, new opportunities

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Influenza vaccination and mortality: differentiating vaccine effects from bias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Immunosenescence: what does it mean to health outcomes in older adults?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

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28 September 2017

Prevention of infectious diseases in older adults through immunization: the challenge of the senescent immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

New strategies are needed to improve the accuracy of influenza vaccine effectiveness estimates among seniors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested case-control study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Effectiveness of influenza vaccine in the community-dwelling elderly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Mortality benefits of influenza vaccination in elderly people: an ongoing controversy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Frailty: an emerging research and clinical paradigm--issues and controversies

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28 September 2017

Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

The role of Granzyme B in atheromatous diseases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Role of T lymphocyte replicative senescence in vaccine efficacy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Evidence of bias in estimates of influenza vaccine effectiveness in seniors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Regional variation in self-reported heart disease prevalence in Canada.

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28 September 2017

The impact of influenza on the health and health care utilisation of elderly people.

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28 September 2017

Respiratory syncytial virus infection in elderly and high-risk adults

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28 September 2017

Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection

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28 September 2017

Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons

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28 September 2017

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians

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28 September 2017

Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation

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28 September 2017

Influenza and the winter increase in mortality in the United States, 1959-1999.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

The impact of influenza epidemics on hospitalizations.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Physiology and complications of bed rest

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 September 2017

Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

31 May 2018

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

31 May 2018

The Effect of Influenza Vaccination on IL2 Production in Healthy Elderly: Implications for Current Vaccination Practices

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

31 May 2018

Predictors of early readmission or death in elderly patients with heart failure

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Evidence of bias in studies of influenza vaccine effectiveness in elderly patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Decline in influenza-associated mortality among Dutch elderly following the introduction of a nationwide vaccination program

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

CTL epitopes for influenza A including the H5N1 bird flu; genome-, pathogen-, and HLA-wide screening.

1 reference

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28 November 2018

Determinants of physical health in frail older people: the importance of self-efficacy

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28 November 2018

No apoptotic deaths and different levels of inductions of inflammatory cytokines in alveolar macrophages infected with influenza viruses

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28 November 2018

Development and validation of a clinical prediction rule for hospitalization due to pneumonia or influenza or death during influenza epidemics among community-dwelling elderly persons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Granzyme B in Atherosclerosis and Transplant Vascular Disease: Association with Cell Death and Atherosclerotic Disease Severity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study

1 reference

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28 November 2018

Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Impact of respiratory virus infections on persons with chronic underlying conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Split-virus influenza vaccines: do they provide adequate immunity in the elderly?

1 reference

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28 November 2018

The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Vaccine-related determinants of the interleukin-2 response to influenza vaccination in healthy young and elderly adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3345132

28 November 2018

Effect of 10 days of bed rest on skeletal muscle in healthy older adults

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Influence of high-risk medical conditions on the effectiveness of influenza vaccination among elderly members of 3 large managed-care organizations

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Frailty in elderly people

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Immunological responses to pneumococcal vaccine in frail older people

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Prevaccine Determination of the Expression of Costimulatory B7 Molecules in Activated Monocytes Predicts Influenza Vaccine Responses in Young and Older Adults

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Granzymes in disease: bench to bedside

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

T cell responses are better correlates of vaccine protection in the elderly

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Benefits of influenza vaccine in US elderly--appreciating issues of confounding bias and precision

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https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Immune response to influenza vaccination in a large healthy elderly population

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Influenza hemagglutination-inhibition antibody titer as a correlate of vaccine-induced protection

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Standardization and validation of assays determining cellular immune responses against influenza

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women

1 reference

https://api.crossref.org/works/10.1016%2FJ.VACCINE.2012.01.015

7 January 2021

Influence of training and of inactivity on muscle strength

1 reference

https://pubmed.ncbi.nlm.nih.gov/22289511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteinase inhibitor 9 is reduced in human atherosclerotic lesion development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22289511

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.VACCINE.2012.01.015

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

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