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Driving neural regeneration through the mammalian target of rapamycin
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Europe PubMed Central
title
Driving neural regeneration through the mammalian target of rapamycin
(English)
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main subject
sirolimus
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inferred from title
author name string
Kenneth Maiese
series ordinal
1
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language of work or name
English
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PubMed
publication date
1 August 2014
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PubMed
published in
Neural Regeneration Research
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stated in
PubMed
volume
9
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PubMed
issue
15
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PubMed
page(s)
1413-7
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PubMed
cites work
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Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin
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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
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Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
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Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury
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Hypothalamic mTOR signaling regulates food intake
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GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway
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RTP801/REDD1 regulates the timing of cortical neurogenesis and neuron migration
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Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms
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Excitotoxic glutamate insults block autophagic flux in hippocampal neurons
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The AMPK inhibitor compound C is a potent AMPK-independent antiglioma agent
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Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia
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28 September 2017
Oxidant stress and signal transduction in the nervous system with the PI 3-K, Akt, and mTOR cascade
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28 September 2017
PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection
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Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia
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28 September 2017
WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy
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28 September 2017
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity
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28 September 2017
Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL.
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PubMed Central
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28 September 2017
Autophagy in hypoxia-ischemia induced brain injury.
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28 September 2017
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease
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PubMed Central
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28 September 2017
New strategies for Alzheimer's disease and cognitive impairment
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28 September 2017
Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells
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28 September 2017
A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death
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28 September 2017
New avenues of exploration for erythropoietin
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PubMed Central
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28 September 2017
Reduction in ischemic cerebral infarction is mediated through golgi phosphoprotein 3 and Akt/mTOR signaling following salvianolate administration.
1 reference
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PubMed Central
reference URL
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28 November 2018
Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
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28 November 2018
EGB1212 post-treatment ameliorates hippocampal CA1 neuronal death and memory impairment induced by transient global cerebral ischemia/reperfusion
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
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28 November 2018
mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
The AKT/mTOR pathway mediates neuronal protective effects of erythropoietin in sepsis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
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28 November 2018
Ferulic acid attenuates focal cerebral ischemia-induced decreases in p70S6 kinase and S6 phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
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28 November 2018
Transplantation of bone marrow‑derived endothelial progenitor cells overexpressing Delta‑like‑4 enhances functional neovascularization in ischemic myocardium
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
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28 November 2018
Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
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28 November 2018
PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
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28 November 2018
Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4192939
retrieved
28 November 2018
Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25317149
retrieved
12 December 2020
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inferred from PubMed ID database lookup
Identifiers
DOI
10.4103/1673-5374.139453
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
818677
OpenCitations bibliographic resource ID
818677
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
818677
PMCID
4192939
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
818677
PubMed ID
25317149
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
818677
ResearchGate publication ID
266946391
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