(Q27105152)

Dehydrocostus lactone (English)

(3aR,6aS,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one

5 October 2016

stereoisomer of

1 reference

based on heuristic

inferred from InChI

chemical formula

C₁₅H₁₈O₂

1 reference

Dehydrocostus lactone (English)

18 November 2016

canonical SMILES

C=C1CCC2C(C3C1CCC3=C)OC(=O)C2=C

1 reference

Dehydrocostus lactone (English)

18 November 2016

isomeric SMILES

C=C1CC[C@@H]2[C@@H]([C@@H]3[C@H]1CCC3=C)OC(=O)C2=C

1 reference

Sesquiterpene lactones and phenylpropanoids from Cosmos pringlei

Dehydrocostus lactone (English)

18 November 2016

1 reference

Costus

1 reference

Antimycobacterial activities of dehydrocostus lactone and its oxidation products

Laurus novocanariensis

2 references

Synergistic antimycobacterial activities of sesquiterpene lactones from Laurus spp.

Effects of a hexane extract from Laurus novocanariensis leaves on the ethanol metabolism of Wistar rats.

Targionia lorbeeriana

1 reference

New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana

Arctium lappa

1 reference

Volatile constituents of Arctium lappa Linn.

Aristolochia yunnanensis

1 reference

A non-oxidized melampolide and other germacranolides from Aristolochia yunnanensis

Cynara scolymus

1 reference

Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action

Gochnatia hypoleuca

1 reference

Dimeric guaianolides and other constituents from Gochnatia species

Gochnatia vernonioides

1 reference

Germacranolides from Gochnatia vernonioides

Hieracium intybaceum

1 reference

Eudesmane Derivatives fromHieracium intybaceum

Laurobasidium lauri

1 reference

Sesquiterpene lactones from Carpesium divaricatum

Liabum bourgeaui

2 references

Sesquiterpenes from Liabum floribundum

Sesquiterpenes from Liabum floribundum

Maclura cochinchinensis

1 reference

A cytotoxic isoflavone from Cudrania cochinchinensis

Mikania hoehnei

1 reference

Sesquiterpene lactones and other chemical constituents of Mikania hoehnei R.

Picris altissima

2 references

Guaianolides fromPicris altissima

Guaianolides fromPicris altissima

Saussurea involucrata

3 references

Further guaianolides from Hymenopappus species

Guaianolides from Saussurea involucrata

Components of the Essential Oil of Saussurea involucrata (Kar. et Kir.) ex Maxim

Eremanthus erythropappus

1 reference

Selective Extraction of α-Methylene-γ-Lactones. Reinvestigation of Vanillosmopsis erythropappa

Dolomiaea souliei

1 reference

Sesquiterpene lactones from Vladimiria souliei

Brachylaena discolor var. transvaalensis

1 reference

Sesquiterpene lactones from Brachylaena species

Cirsium carolinianum

1 reference

Aplotaxene epoxide from Cirsium hypoleucum

Eremanthus bicolor

1 reference

Sesquiterpene lactones from Eremanthus species

Paralychnophora bicolor

1 reference

Sesquiterpene lactones from Eremanthus species

Fitchia speciosa

1 reference

New sesquiterpene lactones and other constituents from Fitchia speciosa

Moquiniastrum paniculatum

1 reference

Dimeric sesquiterpene lactones and kolavane derivatives from Gochnatia paniculata

Inula helenium

1 reference

Structural determination of three new eudesmanolides from Inula helenium

Lindera aggregata

1 reference

Sesquiterpenoids from the root tubers of Lindera aggregata.

Magnolia sieboldii

1 reference

Naphthalene—a constituent of Magnolia flowers

Marshallia obovata

1 reference

Chromones and flavans from Marshallia obovata

Linzia glabra

1 reference

Hirsutinolides from South African Vernonia species

Dolomiaea costus

17 references

Cytotoxic Principles fromSaussurea LappaandCorydalis Turtshaninovii f. Yanhusuo

Guaianolides from Saussurea lappa

Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages

Absolute Stereostructures and Syntheses of Saussureamines A, B, C, D and E, Amino Acid–Sesquiterpene Conjugates with Gastroprotective Effect, from the Roots of Saussurea lappa

Vasoactive substances from Saussurea lappa

Costunolide and dehydrocostus lactone as inhibitors of killing function of cytotoxic T lymphocytes

Bio-antimutagenic effects of sesquiterpene lactones from costus root oil.

Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice.

Cytotoxic sesquiterpene lactones from the root of Saussurea lappa

New sources and antifungal activity of sesquiterpene lactones

A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study

A biologically active guaianolide from Saussurea lappa

A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages

Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa

Gastrointestinal motility enhancing effect of saussureae radix

Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells

Antitrypanosomal sesquiterpene lactones from Saussurea costus.

Lychnophora candelabrum

1 reference

Sesquiterpene lactones from Episcothamnus candelabrum

Pico

2 references

Direct identification and quantitative determination of costunolide and dehydrocostuslactone in the fixed oil of Laurus novocanariensis by 13C-NMR spectroscopy

Two new sesquiterpene lactones from the leaves of Laurus nobilis

Aristolochia griffithii

1 reference

A non-oxidized melampolide and other germacranolides from Aristolochia yunnanensis

Cynara cardunculus

1 reference

Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action

Ainsliaea uniflora

1 reference

Sesquiterpene lactones from Diaspananthus uniflorus (SCH. BIP.) KITAM.

Gymnanthemum myrianthum

1 reference

Sesquiterpene lactones and other constituents of Vernonia species from ethiopia

Orbivestus leopoldii

1 reference

Sesquiterpene lactones and other constituents of Vernonia species from ethiopia

Picris rhagadioloides

1 reference

Guaianolides fromPicris altissima

Identifiers

InChI

InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1

1 reference

Dehydrocostus lactone (English)

NETSQGRTUNRXEO-XUXIUFHCSA-N

18 November 2016

InChIKey

2 references

Dehydrocostus lactone (English)

18 November 2016

ChEBI release 2020-09-01

CAS Registry Number

477-43-0

2 references

Global Substance Registration System

UNII

71TRF5K040

(-)-dehydrocostus lactone (English)

NETSQGRTUNRXEO-XUXIUFHCSA-N

18 November 2016

InChIKey

10 April 2021

https://commonchemistry.cas.org/detail?cas_rn=477-43-0

1 reference

(3aS,6aR,9aR,9bS)-3,6,9-trimethylidenedecahydroazuleno[4,5-b]furan-2(3H)-one (English)

18 November 2016

1 reference

Dehydrocostus lactone (English)

18 November 2016

Reaxys registry number

4733740

1 reference

dehydrocostus lactone (English)

5 October 2016

ChEBI ID

244418

mapping relation type

1 reference

DEHYDROCOSTUSLACTONE (English)

18 November 2016

1 reference

MSBNK-MetaboLights-ML003601

DEHYDROCOSTUSLACTONE (English)

18 November 2016

1 reference

MassBank accession ID

0 references

SPLASH

splash10-00mo-0900000000-f182a3731b82bedcfba5

0 references

DSSTox substance ID

DTXSID80891554

0 references

DSSTOX compound identifier

DTXCID301030647

0 references

EC number

683-106-5

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.208.624

27 December 2018

ECHA Substance Infocard ID

[No public or meaningful name is available] (English)

quotation

CAS no.: 477-43-0 (English)

100.208.624

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.208.624

27 December 2018

[No public or meaningful name is available] (English)

quotation

CAS no.: 477-43-0 (English)

1 reference

Global Substance Registration System

dehydrocostus lactone (English)

5 October 2016

1 reference

UNII

71TRF5K040

(-)-dehydrocostus lactone (English)

18 November 2016

0 references

1 reference

dehydrocostus lactone (English)