(Q27302994)

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Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial

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3 February 2020

Topical insulin accelerates wound healing in diabetes by enhancing the AKT and ERK pathways: a double-blind placebo-controlled clinical trial (English)

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3 February 2020

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3 February 2020

Eliana P Araújo

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3 February 2020

José B Carvalheira

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3 February 2020

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Lício A Velloso

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3 February 2020

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Andréa M Caricilli

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3 February 2020

Lélia L de Abreu

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3 February 2020

Fabiana F Pelegrinelli

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3 February 2020

Ana C P Thirone

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3 February 2020

Daniela M Tsukumo

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3 February 2020

Ana Flávia M Pessoa

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3 February 2020

Marinilce F dos Santos

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3 February 2020

Maria A de Moraes

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3 February 2020

Mario J A Saad

13

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3 February 2020

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25 May 2012

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3 February 2020

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3 February 2020

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3 February 2020

5

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3 February 2020

e36974

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3 February 2020

copyright license

Creative Commons Attribution 4.0 International

25 May 2012

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April 2022 Public Data File from Crossref

copyright status

0 references

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

21 March 2017

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

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21 March 2017

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

21 March 2017

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

21 March 2017

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

21 March 2017

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

21 March 2017

Wound repair and regeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

7 April 2017

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

7 April 2017

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

HB-EGF-induced VEGF production and eNOS activation depend on both PI3 kinase and MAP kinase in HaCaT cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

A role for topical insulin in the management problematic surgical wounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Cellular and molecular basis of wound healing in diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Growth factors in the treatment of diabetic foot ulcers: new technologies, any promises?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

All-trans retinoic acid antagonizes UV-induced VEGF production and angiogenesis via the inhibition of ERK activation in human skin keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor-alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Wound healing and its impairment in the diabetic foot

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Wound healing and collagen formation. I. Sequential changes in components of guinea pig skin wounds observed in the electron microscope

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Insulin signaling pathways in time and space.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Clinical review 125: The insulin receptor and its cellular targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

The regulation of skin proliferation and differentiation in the IR null mouse: implications for skin complications of diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Topical insulin in wound healing: a randomised, double-blind, placebo-controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Insulin stimulates haptotactic migration of human epidermal keratinocytes through activation of NF-kappa B transcription factor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

Topical application of insulin in decubitus ulcers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 September 2017

The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

31 May 2018

Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

31 May 2018

Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

31 May 2018

Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

31 May 2018

Effects of insulin on wound healing in diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

31 May 2018

The use of insulin in open-wound healing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

31 May 2018

Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0036974

21 January 2018

Early steps of insulin action in the skin of intact rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0036974

21 January 2018

Insulin signal transduction through protein kinase cascades.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0036974

21 January 2018

Recombinant human platelet-derived growth factor-BB (becaplermin) for healing chronic lower extremity diabetic ulcers: an open-label clinical evaluation of efficacy.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0036974

21 January 2018

Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0036974

21 January 2018

A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3360697

28 November 2018

Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The diabetic foot

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagenase Production at the Border of Granulation Tissue in a Healing Wound: Macrophage and Mesenchymal Collagenase Productionin Vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen synthesis in rat skin and ileum fibroblasts is affected differently by diabetes-related factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin stimulation of aminoisobutyric acid transport in human skin fibroblasts is mediated through both insulin and type I insulin-like growth factor receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of insulin therapy on burn wound healing in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of topical insulin on infected cutaneous ulcerations in diabetic and nondiabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of topical insulin on cutaneous wound healing in rats with or without acute diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22662132

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0036974

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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3 February 2020

2012PLoSO...736974L

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22662132%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22662132%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

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