(Q27316133)

English

[6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling

scientific article (publication date: 2014)

In more languages

Statements

scholarly article

0 references

[6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling (English)

0 references

apoptotic process

0 references

1 reference

based on heuristic

inferred from title

author name string

E K Radhakrishnan

1

0 references

Smitha V Bava

2

0 references

Sai Shyam Narayanan

3

0 references

Lekshmi R Nath

4

0 references

Arun Kumar T Thulasidasan

5

0 references

Eppurathu Vasudevan Soniya

6

0 references

Ruby John Anto

7

0 references

language of work or name

0 references

publication date

2014

0 references

0 references

9

0 references

8

0 references

e104401

0 references

copyright license

Creative Commons Attribution 4.0 International

26 August 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

Nuclear factor-kB, an unappreciated tumor suppressor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

[6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

Activation of IkappaB kinase beta by protein kinase C isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

The protein kinase C family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

6-Gingerol inhibits hair shaft growth in cultured human hair follicles and modulates hair growth in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

[6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

PAR1-type thrombin receptor stimulates migration and matrix adhesion of human colon carcinoma cells by a PKCepsilon-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

21 March 2017

AP-1 as a regulator of cell life and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

7 April 2017

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

7 April 2017

Epicatechin gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon cancer SW480 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Red ginseng extract reduced metastasis of colon cancer cells in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Dietary patterns and colorectal cancer: systematic review and meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Update on the chemopreventive effects of ginger and its phytochemicals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Examination of the pharmacokinetics of active ingredients of ginger in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

CADPE inhibits PMA-stimulated gastric carcinoma cell invasion and matrix metalloproteinase-9 expression by FAK/MEK/ERK-mediated AP-1 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Colon carcinogenesis: Learning from NF-kappaB and AP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Ginger's (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Cancer preventive properties of ginger: a brief review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

The NF-kappaB-mediated control of ROS and JNK signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

AP-1 and colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Matrix metalloproteinases 9 and 10 inhibit protein kinase C-potentiated, p53-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

The role of bile acids in carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Clonogenic growth of epithelial cells from normal colonic mucosa from both mice and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 September 2017

6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

31 May 2018

Targeted therapy for advanced colorectal cancer--more is not always better

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Chemoprotective properties of some pungent ingredients present in red pepper and ginger.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Activation of protein kinase C augments butyrate-induced differentiation and turnover in human colonic epithelial cells in vitro.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Genotoxic effect of 6-gingerol on human hepatoma G2 cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0104401

21 January 2018

Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4144808

28 November 2018

Ginger: the root of cancer therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25157570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0104401

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2014PLoSO...9j4401R

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q27316133&oldid=1860706136"