(Q27317763)

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Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis

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Plasmodium Infection Is Associated with Impaired Hepatic Dimethylarginine Dimethylaminohydrolase Activity and Disruption of Nitric Oxide Synthase Inhibitor/Substrate Homeostasis (English)

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Aubrey J Cunnington

object named as

Aubrey J Cunnington

5

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Climent Casals-Pascual

object named as

Climent Casals-Pascual

11

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object named as

Joseph Okebe

6

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object named as

Oliver Billker

12

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David J. Conway

object named as

David J Conway

13

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Hans C. Ackerman

15

object named as

Hans Ackerman

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author name string

Jessica H Chertow

1

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Matthew S Alkaitis

2

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Glenn Nardone

3

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Allison K Ikeda

4

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Augustine O Ebonyi

7

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Madi Njie

8

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Simon Correa

9

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Shamanthi Jayasooriya

10

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Michael Walther

14

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language of work or name

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publication date

September 2015

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11

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9

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e1005119

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copyright license

Creative Commons CC0 License

25 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Global malaria mortality between 1980 and 2010: a systematic analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Genome-wide and fine-resolution association analysis of malaria in West Africa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Disruption of methylarginine metabolism impairs vascular homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Farnesoid X receptor agonist reduces serum asymmetric dimethylarginine levels through hepatic dimethylarginine dimethylaminohydrolase-1 gene regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

21 March 2017

Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Comparison of parasite sequestration in uncomplicated and severe childhood Plasmodium falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Impaired skeletal muscle microvascular function and increased skeletal muscle oxygen consumption in severe falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

The neuropathology of fatal cerebral malaria in malawian children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

The DDAH/ADMA pathway in the control of endothelial cell migration and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Cellular ADMA: regulation and action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Asymmetric dimethylarginine induces tissue factor expression in monocytes via NF-kappaB-dependent pathway: Role in acute coronary syndromes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Asymmetric dimethylarginine induces TNF-alpha production via ROS/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

The distribution and intensity of parasite sequestration in comatose Malawian children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Pathogenesis, clinical features, and neurological outcome of cerebral malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Regulation of cationic amino acid transport: the story of the CAT-1 transporter.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Lactic acidosis and hypoglycaemia in children with severe malaria: pathophysiological and prognostic significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Reduced hepatic blood flow and intestinal malabsorption in severe falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

S-Adenosylmethionine:protein-arginine methyltransferase. Purification and mechanism of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 September 2017

Impact of intravascular hemolysis in malaria on liver dysfunction: involvement of hepatic free heme overload, NF-κB activation, and neutrophil infiltration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

31 May 2018

Role of the human erythrocyte in generation and storage of asymmetric dimethylarginine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

31 May 2018

Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

31 May 2018

Anti-Adhesive Effect of Nitric Oxide on Plasmodium falciparum Cytoadherence under Flow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

31 May 2018

Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

31 May 2018

Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

31 May 2018

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

31 May 2018

Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Differentiating the pathologies of cerebral malaria by postmortem parasite counts

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

ADMA regulates angiogenesis: genetic and metabolic evidence

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

The human liver clears both asymmetric and symmetric dimethylarginine

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

The liver is an important organ in the metabolism of asymmetrical dimethylarginine (ADMA).

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Elevation of asymmetric dimethylarginine (ADMA) in patients developing hepatic failure after major hepatectomy.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Clinical features and outcome of severe malaria in Gambian children

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

A prospective comparison of malaria with other severe diseases in African children: prognosis and optimization of management

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Alterations in haptoglobin levels

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

Contribution of whole blood to the control of plasma asymmetrical dimethylarginine.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005119

21 January 2018

The transplanted liver graft is capable of clearing asymmetric dimethylarginine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 November 2018

Acid-base status in paediatric Plasmodium falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4583463

28 November 2018

Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation is an important determinant of levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) in acute liver failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ADMA/DDAH pathway is a critical regulator of endothelial cell motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and Identification of N,N- and N,N' -Dimethylarginine, Nε-Mono-, Di-, and Trimethyllysine, and Glucosylgalactosyl- and Galactosyl-δ-hydroxylysine from Human Urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric dimethylarginine impairs fibrinolytic activity in human umbilical vein endothelial cells via p38 MAPK and NF-κB pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/26407009

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PPAT.1005119

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

release_lul5lvi4i5cmxg4yzljabcomzu

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

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PubMed publication ID

0 references

ResearchGate publication ID

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