(Q27322386)

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TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes

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scholarly article

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TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes (English)

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toll-like receptor

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object named as

Paul F McKay

1

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object named as

Darrick Carter

5

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6

object named as

Robin J Shattock

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2

object named as

Deborah F L King

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3

object named as

Jamie F S Mann

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author name string

Guillermo Barinaga

4

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language of work or name

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publication date

2016

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11

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2

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e0148984

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copyright license

Creative Commons Attribution 4.0 International

10 February 2016

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April 2022 Public Data File from Crossref

copyright status

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TLR cross-talk confers specificity to innate immunity

1 reference

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21 March 2017

Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

21 March 2017

Intranasal administration of a therapeutic HIV vaccine (Vacc-4x) induces dose-dependent systemic and mucosal immune responses in a randomized controlled trial

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28 September 2017

A comparative review of toll-like receptor 4 expression and functionality in different animal species

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Minipigs as an animal model for dermal vaccine delivery

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes

1 reference

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28 September 2017

Mucosal application of gp140 encoding DNA polyplexes to different tissues results in altered immunological outcomes in mice.

1 reference

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28 September 2017

The immune complex CTA1-DD/IgG adjuvant specifically targets connective tissue mast cells through FcγRIIIA and augments anti-HPV immunity after nasal immunization

1 reference

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28 September 2017

Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice

1 reference

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28 September 2017

Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.

1 reference

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28 September 2017

Adjuvants for human vaccines

1 reference

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Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

1 reference

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1 reference

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28 September 2017

The pig: a model for human infectious diseases

1 reference

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Potential of nasopharynx-associated lymphoid tissue for vaccine responses in the airways

1 reference

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28 September 2017

The utility of the minipig as an animal model in regulatory toxicology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Proinflammatory T helper type 17 cells are effective B-cell helpers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Found in translation: the human equivalent of mouse CD8+ dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Enhanced humoral and Type 1 cellular immune responses with Fluzone adjuvanted with a synthetic TLR4 agonist formulated in an emulsion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

TLR accessory molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

The porcine dendritic cell family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

1 reference

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28 September 2017

Mucosal immunity and vaccines

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4749393

28 September 2017

Characterization of a virtually full-length human immunodeficiency virus type 1 genome of a prevalent intersubtype (C/B') recombinant strain in China

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28 September 2017

Generation of female genital tract antibody responses by local or central (common) mucosal immunization

1 reference

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28 September 2017

Intranasal immunization with fusion protein MrpH·FimH and MPL adjuvant confers protection against urinary tract infections caused by uropathogenic Escherichia coli and Proteus mirabilis.

1 reference

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31 May 2018

Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide

1 reference

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31 May 2018

Vaccine adjuvants: a priority for vaccine research.

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21 January 2018

MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists

1 reference

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21 January 2018

CL097, a TLR7/8 ligand, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression.

1 reference

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21 January 2018

Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.

1 reference

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21 January 2018

Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0148984

21 January 2018

Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0148984

21 January 2018

Effects of adjuvants on the immune response of pigs after intradermal administration of antigen

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0148984

21 January 2018

Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0148984

21 January 2018

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https://pubmed.ncbi.nlm.nih.gov/26862758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histological and ultrastructural examinations of porcine tonsils

1 reference

https://pubmed.ncbi.nlm.nih.gov/26862758

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parenteral and mucosal prime-boost immunization strategies in mice with hepatitis B surface antigen and CpG DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/26862758

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0148984

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2016PLoSO..1148984M

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