(Q27330328)

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The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model

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The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model (English)

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molecular chaperones

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Sanford Bernstein

4

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Sanford I Bernstein

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author name string

Girish C Melkani

1

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Rolf Bodmer

2

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Karen Ocorr

3

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publication date

2011

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6

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7

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e22579

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Creative Commons Attribution 4.0 International

25 July 2011

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April 2022 Public Data File from Crossref

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X-ray Crystal Structure of the UCS Domain-Containing UNC-45 Myosin Chaperone from Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

Drawing the tree of eukaryotic life based on the analysis of 2,269 manually annotated myosins from 328 species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

21 March 2017

Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky ticker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Sarcomere gene mutations in hypertrophy and heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Fluorescent labeling of Drosophila heart structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Semi-automated Optical Heartbeat Analysis of small hearts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Build it up-Tear it down: protein quality control in the cardiac sarcomere

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Impact of multiple gene mutations in determining the severity of cardiomyopathy and heart failure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Loss of unc45a precipitates arteriovenous shunting in the aortic arches.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Signalling pathways involved in adult heart formation revealed by gene expression profiling in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Genetic control of heart function and aging in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Hereditary myosin myopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Drosophila as a model for the identification of genes causing adult human heart disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

UCS protein Rng3p activates actin filament gliding by fission yeast myosin-II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

UCS proteins: managing the myosin motor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Control of cardiac development by an evolutionarily conserved transcriptional network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

The Genetic Basis for Cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Myosin II folding is mediated by a molecular chaperonin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Unc-45 mutations in Caenorhabditis elegans implicate a CRO1/She4p-like domain in myosin assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Genetic approaches to understanding muscle development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

28 September 2017

Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

2 June 2018

Temperature-sensitive mutation affecting myofilament assembly in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

2 June 2018

Structure and function of contractile proteins in human dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

2 June 2018

Myosin assembly, maintenance and degradation in muscle: Role of the chaperone UNC-45 in myosin thick filament dynamics

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

Alpha B-crystallin mutation in dilated cardiomyopathy

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0022579

21 January 2018

Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

27 November 2018

Morphology of the pupal heart, adult heart, and associated tissues in the fruit fly, Drosophila melanogaster.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3143160

27 November 2018

Fission yeast Rng3p: an UCS-domain protein that mediates myosin II assembly during cytokinesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential Expression of Heat Shock Proteins in Normal and Failing Human Hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799905

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0022579

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2011PLoSO...622579M

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