(Q27332112)

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Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells

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scholarly article

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Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells (English)

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object named as

Clare M Waterman

5

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Gaudenz Danuser

4

object named as

Gaudenz Danuser

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author name string

Yukako Nishimura

1

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Kathryn Applegate

2

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Michael W Davidson

3

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language of work or name

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publication date

2012

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7

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7

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e41413

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copyright license

Creative Commons CC0 License

24 July 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Cytoplasmic linker proteins promote microtubule rescue in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Asef, a link between the tumor suppressor APC and G-protein signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Cellular motility driven by assembly and disassembly of actin filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Rho GTPases in cell biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Rho GTPases and the actin cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

ACF7: an essential integrator of microtubule dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Identification of katanin, an ATPase that severs and disassembles stable microtubules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

21 March 2017

Conserved microtubule-actin interactions in cell movement and morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

7 April 2017

Biology of the p21-activated kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

7 April 2017

Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

A PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Analysis of microtubule dynamic instability using a plus-end growth marker

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

APC2 plays an essential role in axonal projections through the regulation of microtubule stability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

The tau of MARK: a polarized view of the cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

GSK3beta phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

The regulation and function of mammalian AMPK-related kinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

The PAR proteins: fundamental players in animal cell polarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

The MAP1 family of microtubule-associated proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

GSK-3beta directly phosphorylates and activates MARK2/PAR-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Regulation of leading edge microtubule and actin dynamics downstream of Rac1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Organization and dynamics of growing microtubule plus ends during early mitosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Dual-wavelength fluorescent speckle microscopy reveals coupling of microtubule and actin movements in migrating cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Regulation of substrate adhesion dynamics during cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Drosophila par-1 is required for oocyte differentiation and microtubule organization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

Purification and assay of a 145-kDa protein (STOP145) with microtubule-stabilizing and motility behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

The periodic association of MAP2 with brain microtubules in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

28 September 2017

plusTipTracker: Quantitative image analysis software for the measurement of microtubule dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

2 June 2018

Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

2 June 2018

The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

2 June 2018

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

2 June 2018

Interaction of microtubule-associated protein 2 with actin filaments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

2 June 2018

The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0041413

21 January 2018

Common and divergent roles for members of the mouse DCX superfamily.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0041413

21 January 2018

Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0041413

21 January 2018

Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0041413

21 January 2018

Glycogen synthase kinase (GSK) 3beta directly phosphorylates Serine 212 in the regulatory loop and inhibits microtubule affinity-regulating kinase (MARK) 2.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0041413

21 January 2018

Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0041413

21 January 2018

Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404095

27 November 2018

The interaction of actin filaments with microtubules and microtubule-associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22848487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional regulation of microtubule dynamics in polarized, motile cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22848487

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0041413

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2012PLoSO...741413N

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